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绿茶表没食子儿茶素没食子酸酯对皮肤创伤愈合的有益作用：全面综述。

Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review.

机构信息

Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, China.

Tea Research Institute, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310013, China.

出版信息

Molecules. 2021 Oct 11;26(20):6123. doi: 10.3390/molecules26206123.

DOI:10.3390/molecules26206123
PMID:34684703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8540743/
Abstract

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

摘要

没食子酸表没食子儿茶精（EGCG）与多种健康益处有关。在这篇综述中，我们搜索了关于 EGCG 及其在皮肤伤口愈合方面的伤口敷料的最新研究。水凝胶、纳米粒子、微/纳米纤维网络和微针是含 EGCG 的伤口敷料的主要类型。根据抗氧化、抗炎、抗菌、血管生成和抗纤维化特性的潜在机制，总结了 EGCG 及其伤口敷料在皮肤伤口愈合的不同阶段（止血、炎症、增殖和组织重塑）的有益作用。本综述阐述了使用 EGCG 促进皮肤伤口愈合和预防瘢痕形成的原理，为 EGCG 的未来临床应用方向提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/84e59e779706/molecules-26-06123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/100323e58189/molecules-26-06123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/c2691d957d12/molecules-26-06123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/84e59e779706/molecules-26-06123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/100323e58189/molecules-26-06123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/c2691d957d12/molecules-26-06123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fda/8540743/84e59e779706/molecules-26-06123-g003.jpg

相似文献

[1]
Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review.

Molecules. 2021-10-11

[2]
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[3]
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[4]
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[5]
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[6]
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Clin Exp Pharmacol Physiol. 2016-11

[7]
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Adv Healthc Mater. 2024-5

[8]
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[9]
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[10]
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引用本文的文献

[1]
Comprehensive Evaluation of the Safety and Efficacy of MOSY PHYCOLLREPAIR: A Novel Fermented Black Bee Honey-Derived Cosmetic Ingredient.

J Cosmet Dermatol. 2025-8

[2]
Poloxamer-based hydrogel with EGCG and rhEGF for diabetic foot ulcer treatment.

J Mater Sci Mater Med. 2025-8-11

[3]
Comparative effectiveness of plant-derived compounds in keloid management: a review.

Front Pharmacol. 2025-7-16

[4]
Oligomeric hyaluronic acid-modified liposomes effectively improved skin permeability and anti-ageing activity of ellagic acid.

Sci Rep. 2025-7-26

[5]
Efficacy and Safety of Epigallocatechin Gallate in the Treatment and Prevention of Dermatitis: A Systematic Review.

Biomedicines. 2025-6-13

[6]
Beyond Cannabidiol: The Contribution of Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes.

Pharmaceuticals (Basel). 2025-4-28

[7]
Mechanisms underlying the wound healing and tissue regeneration properties of a novel gauze dressing impregnated with traditional herbal medicine (Ya-Samarn-Phlae) in type 2 diabetic Goto-Kakizaki (GK) rats.

Front Pharmacol. 2025-4-9

[8]
Recent Research Progress of Wound Healing Biomaterials Containing Platelet-Rich Plasma.

Int J Nanomedicine. 2025-3-31

[9]
Modulating Polyphenol Activity with Metal Ions: Insights into Dermatological Applications.

Pharmaceutics. 2025-2-4

[10]
Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline.

Front Pharmacol. 2025-1-31

本文引用的文献

[1]
Polycaprolactone/Gelatin Nanofiber Membranes Containing EGCG-Loaded Liposomes and Their Potential Use for Skin Regeneration.

ACS Appl Bio Mater. 2019-11-18

[2]
Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β.

Cell Signal. 2021-11

[3]
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases.

Nat Commun. 2021-6-17

[4]
Epigallocatechin gallate/L-ascorbic acid-loaded poly-γ-glutamate microneedles with antioxidant, anti-inflammatory, and immunomodulatory effects for the treatment of atopic dermatitis.

Acta Biomater. 2021-8

[5]
EGCG-Mediated Potential Inhibition of Biofilm Development and Quorum Sensing in .

Int J Mol Sci. 2021-5-6

[6]
Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management.

Materials (Basel). 2021-3-4

[7]
A retrospective review of the use of a nanocrystalline silver dressing in the management of open chronic wounds in the community.

Int Wound J. 2021-12

[8]
Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles.

Mater Sci Eng C Mater Biol Appl. 2021-1

[9]
Inhibition of Biofilm Formation by the Synergistic Action of EGCG-S and Antibiotics.

Antibiotics (Basel). 2021-1-21

[10]
Antioxidant and Antimicrobial Activities of (-)-Epigallocatechin-3-gallate (EGCG) and its Potential to Preserve the Quality and Safety of Foods.

Compr Rev Food Sci Food Saf. 2018-5

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