Butler K W
J Pharm Sci. 1975 Mar;64(3):497-501. doi: 10.1002/jps.2600640339.
The electron spin resonance spectra of probes were used to study the organization and motion of molecules in hydrated stacked bilayer or liposome model membrane systems. The same steroid structures required for reduction of membrane permeability were required to produce well-ordered films of brain lipid. Alcohols and anesthetic agents influence the structure of model membranes, with their order of efficacy paralleling their pharmacological effectiveness. Spin probes were also used to demonstrate effects of calcium and local anesthetics on the rate of penetration of ascorbate into lipid bilayers.
利用探针的电子自旋共振光谱来研究水合堆叠双层或脂质体模型膜系统中分子的组织和运动。降低膜通透性所需的相同类固醇结构对于产生有序的脑脂质膜也是必需的。醇类和麻醉剂会影响模型膜的结构，其效力顺序与其药理作用效果平行。自旋探针还用于证明钙和局部麻醉剂对抗坏血酸渗透到脂质双层速率的影响。
