椎间盘的分子治疗
Molecular therapy of the intervertebral disc.
作者信息
Yoon S Tim, Patel Nilpesh M
机构信息
Department of Orthopaedic Surgery, Emory Spine Center, Emory University, 59 Executive Park S. STE 3000, Atlanta, GA 30029, USA.
出版信息
Eur Spine J. 2006 Aug;15 Suppl 3(Suppl 3):S379-88. doi: 10.1007/s00586-006-0155-3. Epub 2006 Jul 12.
Abstract
Disc degeneration is the loss of the normal nucleus pulposus disc matrix to a more fibrotic and less cartilaginous structure. This change in disc micro-anatomy can be associated with pain and deformity, however, prevention and treatment options of disc degeneration are currently limited. Much research is going on to understand intervertebral discs at a molecular/ cellular level in hopes of creating clinically applicable options for treating disc degeneration. This review article will give insight into the current and developing status of treating intervertebral disc degeneration from a molecular standpoint.
摘要
椎间盘退变是指正常的椎间盘髓核基质丧失，转变为更纤维化且软骨化程度更低的结构。椎间盘微观解剖结构的这种变化可能与疼痛和畸形相关，然而，目前椎间盘退变的预防和治疗选择有限。目前正在进行大量研究，以在分子/细胞水平上了解椎间盘，希望能创造出临床上可应用的治疗椎间盘退变的方法。这篇综述文章将从分子角度深入探讨治疗椎间盘退变的现状和发展态势。
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