Wang Shan-zheng, Chang Qing, Lu Jun, Wang Chen
Department of Orthopaedics, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu, 210009, People's Republic of China.
Int Orthop. 2015 May;39(5):927-34. doi: 10.1007/s00264-014-2664-8. Epub 2015 Feb 5.
Intervertebral disc degeneration (IDD) is a complex process with the mechanism not fully elucidated. The current clinical treatments for IDD are mainly focused on providing symptomatic relief without addressing the underlying cause of the IDD. Biological therapeutic strategies to repair and regenerate the degenerated discs are drawing more attention. Growth factor therapy is one of the biological strategies and holds promising prospects. As a promising bioactive substance, platelet-rich plasma (PRP) is considered to be an ideal growth factor "cocktail" for intervertebral disc (IVD) restoration. Results from many in vitro and in vivo studies have confirmed the efficacy of growth factors and PRP in IVD repair and regeneration. It is essential to advance the research on growth factor therapy and associated mechanism for IDD. This article reviews the background of IDD, current concepts in growth factor and PRP-related therapy for IDD. Future research perspectives and clinical directions are also discussed.
椎间盘退变（IDD）是一个复杂的过程，其机制尚未完全阐明。目前针对IDD的临床治疗主要集中在缓解症状，而未解决IDD的根本原因。修复和再生退变椎间盘的生物治疗策略正受到越来越多的关注。生长因子治疗是生物治疗策略之一，具有广阔的前景。作为一种有前景的生物活性物质，富血小板血浆（PRP）被认为是用于椎间盘（IVD）修复的理想生长因子“鸡尾酒”。许多体外和体内研究的结果证实了生长因子和PRP在IVD修复和再生中的疗效。推进生长因子治疗及其相关机制在IDD方面的研究至关重要。本文综述了IDD的背景、生长因子及PRP相关治疗IDD的当前概念。还讨论了未来的研究前景和临床方向。
