使用N,N-双（乙氧基甲基）烷基胺试剂对环状酮进行双曼尼希环化反应。
Double-Mannich annulation of cyclic ketones using N,N-Bis(ethoxymethyl)alkylamine reagents.
作者信息
Halliday Jill I, Chebib Mary, Turner Peter, McLeod Malcolm D
机构信息
School of Chemistry, F11, and Faculty of Pharmacy, A15, University of Sydney, Camperdown, NSW 2006, Australia.
出版信息
Org Lett. 2006 Jul 20;8(15):3399-401. doi: 10.1021/ol061242s.
PMID:16836415
Abstract
[Structure: see text] N,N-Bis(ethoxymethyl)alkylamines function as effective reagents in the double-Mannich annulation of cyclic ketone substrates, providing efficient access to a series of azabicyclic ketones. These ring systems are a useful scaffold for the four-step synthesis of novel constrained homocholine analogues.
摘要
[结构：见正文] N,N-双（乙氧基甲基）烷基胺在环状酮底物的双曼尼希环化反应中作为有效试剂，能高效合成一系列氮杂双环酮。这些环系是用于新颖的受限高胆碱类似物四步合成的有用骨架。
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