Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, New Jersey 08544, USA.
Org Lett. 2010 Jun 18;12(12):2746-9. doi: 10.1021/ol100845z.
When ketones flanked on both sides by nucleophilic atoms react with Seebach's nitropropenyl pivaloate reagent, direct couplings take place to give two new ring systems and three bonds. Cis-ring fusions are observed in unions leading to 5,5-, 5,6-, and 6,6-bicycles. Densely functionalized and rigid frameworks may be rapidly formed by the chemistry described herein.
当两侧被亲核原子包围的酮与 Seebach 的硝基丙烯异丁酸酯试剂反应时,会发生直接偶联反应,生成两个新的环系统和三个键。在导致 5,5-、5,6-和 6,6-双环的键合中观察到顺式环融合。本文所述的化学可以快速形成功能丰富且刚性的骨架。