导向基团增强了氨基取代的环丙烷的羰基环化反应：铑催化的 N-杂双环烯酮的多组分合成。
Directing group enhanced carbonylative ring expansions of amino-substituted cyclopropanes: rhodium-catalyzed multicomponent synthesis of N-heterobicyclic enones.
机构信息
School of Chemistry, University of Bristol , Bristol BS8 1TS, United Kingdom.
出版信息
J Am Chem Soc. 2013 Apr 3;135(13):4992-5. doi: 10.1021/ja401936c. Epub 2013 Mar 22.
PMID:23488745
Abstract
Aminocyclopropanes equipped with suitable N-directing groups undergo efficient and regioselective Rh-catalyzed carbonylative C-C bond activation. Trapping of the resultant metallacycles with tethered alkynes provides an atom-economic entry to diverse N-heterobicyclic enones. These studies provide a blueprint for myriad N-heterocyclic methodologies.
摘要
带有合适 N-导向基团的氨环丙烷经历高效和区域选择性的 Rh 催化羰基化 C-C 键活化。所得金属环的与桥连炔烃的捕获提供了一种原子经济性的方法，用于获得多种 N-杂双环烯酮。这些研究为众多 N-杂环方法学提供了蓝图。
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