Colditz I G
CSIRO Division of Animal Health, Armidale, NSW, Australia.
Immunol Cell Biol. 1991 Jun;69 ( Pt 3):215-9. doi: 10.1038/icb.1991.31.
Vascular leakage of [125I]-human serum albumin into the skin of sheep was measured in response to intradermal injection of histamine, bradykinin, zymosan-activated plasma (ZAP), platelet-activating factor (PAF) and serotonin. Potency of the mediators was PAF greater than ZAP greater than bradykinin approximately histamine greater than serotonin. Maximal leakage occurred in the first 10 min following injection of bradykinin, histamine and PAF, and for histamine and bradykinin had effectively ceased by 40 min. In contrast, ZAP and serotonin induced relatively constant plasma leakage over the first 40 min following their intradermal injection. Prostaglandins E1 and E2 enhanced plasma leakage induced by histamine and bradykinin thus confirming the applicability of the two-mediator hypothesis of vascular leakage to permeability responses in skin of sheep.
通过皮内注射组胺、缓激肽、酵母聚糖激活血浆（ZAP）、血小板活化因子（PAF）和5-羟色胺，测定了[125I] -人血清白蛋白向绵羊皮肤的血管渗漏情况。这些介质的效力为PAF大于ZAP大于缓激肽约等于组胺大于5-羟色胺。缓激肽、组胺和PAF注射后的前10分钟出现最大渗漏，组胺和缓激肽在40分钟时渗漏有效停止。相比之下，ZAP和5-羟色胺皮内注射后的前40分钟诱导相对恒定的血浆渗漏。前列腺素E1和E2增强了组胺和缓激肽诱导的血浆渗漏，从而证实了血管渗漏的双介质假说适用于绵羊皮肤的通透性反应。
