Lewis Gregory S, Wulster-Radcliffe Meghan C
USDA, ARS, US Sheep Experiment Station, Dubois, ID 83423, USA.
Am J Reprod Immunol. 2006 Aug;56(2):102-11. doi: 10.1111/j.1600-0897.2006.00391.x.
Uterine infections often develop in some livestock species during the first luteal phase postpartum. Exogenous prostaglandin F(2alpha) (PGF(2alpha)) induces luteolysis, reduces progesterone, and enables the uterus to resolve infections. However, the effects of PGF(2alpha) on luteal function and on immune functions are confounded. These effects must be disentangled to determine whether alternatives to antibiotic treatments can be successfully developed.
Treatments were in a 2 x 2 x 2 factorial arrangement. Main effects were ovariectomy or sham on day 0 (i.e. estrus), exogenous progesterone or sesame oil from day 0 to 11, and exogenous PGF(2alpha) or saline on day 9. Intrauterine inoculations with Arcanobacterium pyogenes and Escherichia coli were administered on day 6.
Ewes treated with exogenous PGF(2alpha) either did not have uterine infections, infections were less severe, or infections were resolving when uteri were examined on day 12, despite increased progesterone.
Exogenous PGF(2alpha) has effects on the resolution of uterine infections that are independent of its effects on luteal progesterone production.
在产后第一个黄体期，一些家畜物种常会发生子宫感染。外源性前列腺素F（2α）（PGF（2α））可诱导黄体溶解，降低孕酮水平，并使子宫能够消除感染。然而，PGF（2α）对黄体功能和免疫功能的影响相互混淆。必须厘清这些影响，以确定是否能够成功开发抗生素治疗的替代方法。
采用2×2×2析因设计。主要处理因素为在第0天（即发情期）进行卵巢切除术或假手术，从第0天至第11天给予外源性孕酮或芝麻油，以及在第9天给予外源性PGF（2α）或生理盐水。在第6天进行子宫内接种化脓隐秘杆菌和大肠杆菌。
尽管孕酮水平升高，但在第12天检查子宫时，接受外源性PGF（2α）治疗的母羊要么没有子宫感染，要么感染较轻，要么感染正在消退。
外源性PGF（2α）对子宫感染的消退有影响，且这种影响与其对黄体孕酮产生的影响无关。
