阿替美唑，一种α2拮抗剂，可稳定与年龄相关的高电压纺锤波和被动回避缺陷。

Atipamezole, an alpha 2 antagonist, stabilizes age-related high-voltage spindle and passive avoidance defects.

作者信息

Riekkinen P, Sirviö J, Riekkinen M, Lammintausta R, Riekkinen P

机构信息

Department of Neurology, University of Kuopio, Finland.

出版信息

Pharmacol Biochem Behav. 1992 Mar;41(3):611-4. doi: 10.1016/0091-3057(92)90381-o.

DOI:10.1016/0091-3057(92)90381-o

PMID:1350102

Abstract

The present study investigates the effects of an alpha 2 antagonist, atipamezole (Ati), on the high-voltage spindle (HVS; Ati at 0.1, 1.0, and 3.0 mg/kg) activity, passive avoidance retention (PA; Ati at 3 mg/kg; injected before retention trial), and water maze (WM; Ati at 3 mg/kg; injected after daily training trials) acquisition of young and aged rats. PA retention trial performance defect of aged rats was partially alleviated by Ati at a 3-mg/kg dose. Ati at 3 mg/kg had no effect on the PA performance of young rats. Retention trial performance of nonshocked young or aged rats was not altered by a 3-mg/kg Ati dose. WM acquisition was not affected by posttraining Ati injections. Age-related increase of HVS was stabilized by Ati at 1 or 3 mg/kg. Ati at 1 and 3 mg/kg completely suppressed HVS of young rats. Ati at 0.1 mg/kg had no effect on HVS of young or aged rats. The results suggest that alpha 2-antagonist-administration-induced increase in noradrenergic activity may stabilize age-related HVS activity increase and PA performance defect.

摘要

本研究调查了α2拮抗剂阿替美唑（Ati）对幼龄和老龄大鼠的高压纺锤波（HVS；Ati剂量为0.1、1.0和3.0mg/kg）活动、被动回避记忆保持（PA；Ati剂量为3mg/kg；在记忆保持试验前注射）以及水迷宫（WM；Ati剂量为3mg/kg；在每日训练试验后注射）学习的影响。3mg/kg剂量的Ati可部分缓解老龄大鼠的PA记忆保持试验表现缺陷。3mg/kg的Ati对幼龄大鼠的PA表现无影响。3mg/kg剂量的Ati对未受电击的幼龄或老龄大鼠的记忆保持试验表现无改变。训练后注射Ati不影响WM学习。1或3mg/kg的Ati可稳定与年龄相关的HVS增加。1和3mg/kg的Ati完全抑制幼龄大鼠的HVS。0.1mg/kg的Ati对幼龄或老龄大鼠的HVS无影响。结果表明，给予α2拮抗剂诱导的去甲肾上腺素能活性增加可能会稳定与年龄相关的HVS活动增加和PA表现缺陷。