Ibrahim Yehia, Tang Keqi, Tolmachev Aleksey V, Shvartsburg Alexandre A, Smith Richard D
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
J Am Soc Mass Spectrom. 2006 Sep;17(9):1299-305. doi: 10.1016/j.jasms.2006.06.005. Epub 2006 Jul 12.
We report on a new electrodynamic ion funnel that operates at a pressure of 30 torr with no loss of ion transmission. The enhanced performance compared with previous ion funnel designs optimized for pressures of <5 torr was achieved by reducing the ion funnel capacitance and increasing the RF drive frequency (1.7 MHz) and amplitude (100-170 V peak-to-peak). No degradation of ion transmission was observed for pressures from 2 to 30 torr. The ability to operate at higher pressure enabled a new tandem ion funnel mass spectrometer interface design that can accommodate a greater gas load (e.g., from an ESI source). When combined with a multicapillary inlet, the interface provided more efficient introduction of ions, resulting in a significant enhancement in mass spectrometer sensitivity and detection limits.
我们报道了一种新型的电动离子漏斗，它在30托的压力下运行，且离子传输无损失。与之前针对低于5托压力优化的离子漏斗设计相比，通过降低离子漏斗电容、提高射频驱动频率（1.7兆赫兹）和幅度（峰峰值100 - 170伏）实现了性能增强。在2至30托的压力范围内未观察到离子传输性能下降。在更高压力下运行的能力促成了一种新的串联离子漏斗质谱仪接口设计，该设计能够承受更大的气体负载（例如来自电喷雾电离源）。当与多毛细管入口相结合时，该接口能更高效地引入离子，从而显著提高了质谱仪的灵敏度和检测限。
