Ambler R P, Daniel M
Institute of Cell and Molecular Biology, University of Edinburgh, U.K.
Philos Trans R Soc Lond B Biol Sci. 1991 Sep 30;333(1268):381-9. doi: 10.1098/rstb.1991.0088.
Protein taxonomy has existed as a concept at least since 1958, but despite the efforts of the past 30 years, comparative studies of protein sequence, structure and distribution have not revolutionized any areas of systematics. The most interesting results of single gene phylogenies have been the anomalies, such as insulin in hystricomorphs or cytochrome c in the rattlesnake. It is likely that protein sequence information can be obtained in sufficient quality and quantity from ancient material as to change this finding? The paper will assess possibilities and the likely limitations of chemical studies of ancient protein material.
蛋白质分类学作为一个概念至少自1958年就已存在，但尽管在过去30年里人们付出了诸多努力，对蛋白质序列、结构和分布的比较研究并未给系统分类学的任何领域带来变革。单基因系统发育研究最有趣的结果一直是一些异常情况，比如豪猪亚目动物体内的胰岛素或响尾蛇体内的细胞色素c。是否有可能从古代材料中获取质量和数量都足够的蛋白质序列信息，从而改变这一发现呢？本文将评估对古代蛋白质材料进行化学研究的可能性及其可能存在的局限性。
