Ech-Charif Soumaya, Aubert Sébastien, Buob David, Verhulst Priscilla, Blomme Valérie, Migaud Henri, Leroy Xavier
Service d'Anatomie Pathologique, CHRU, Pôle Biologie Pathologie, Eurasanté, Avenue Oscar Lambret, 59037 Lille Cedex.
Ann Pathol. 2006 Feb;26(1):26-9. doi: 10.1016/s0242-6498(06)70657-5.
We report two cases of giant-cell tumour of soft tissue (TCG-TM). The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg. Pathological study revealed a tumour comparable to benign giant cell tumour of bone. The patient is well without recurrence 10 months after the diagnosis. The second case concerned a 49-year-old man with a huge mass of the thigh. Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells. Mononuclear cells presented severe atypia and a high mitotic activity. Eighteen months later, the patient died with diffuse pulmonary metastases. TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone. The malignant variant is debatable. The differential diagnosis includes other tumours rich in osteoclast-like cells.
我们报告两例软组织巨细胞瘤（TCG-TM）。第一例发生在一名26岁女性身上，表现为左腿皮下肿瘤。病理研究显示肿瘤类似于骨良性巨细胞瘤。诊断后10个月患者情况良好，无复发。第二例涉及一名49岁男性，大腿有巨大肿块。显微镜下，肿瘤由单核和多核细胞片组成。单核细胞呈现严重异型性和高有丝分裂活性。18个月后，患者死于弥漫性肺转移。软组织巨细胞瘤并不常见，是一种独特的实体，其临床行为和组织学特征与骨巨细胞瘤相似。恶性变体存在争议。鉴别诊断包括其他富含破骨细胞样细胞的肿瘤。
