小鼠对牙龈卟啉单胞菌菌毛体液免疫反应的免疫反应基因调控
Immune response gene regulation of the humoral immune response to Porphyromonas gingivalis fimbriae in mice.
作者信息
Shimauchi H, Ogawa T, Hamada S
机构信息
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan.
出版信息
Immunology. 1991 Oct;74(2):362-4.
Among various strains of mice immunized orally with Porphyromonas gingivalis fimbriae and adjuvant GM-53 in liposomes, BALB/c and DBA/2 mice (H-2d) were found to be high responders to the fimbriae, CBA/J and C3H mice (H-2k) were intermediate, while C57BL/6 mice were low responders in terms of serum IgG and salivary IgA responses. Furthermore, humoral immune responses were examined using congeneic mice of B10 background showing different H-2 haplotypes, and it was revealed that B10.D2 mice (H-2d), followed by B10.BR (H-2k), responded well to antigenic stimulation of the fimbriae, while C57BL/10 mice (B10, H-2b) were low responders to the fimbriae. Hybrids between BALB/c and C57BL/6 mice were found to reflect a phenotype of low responders. Thus, the humoral immune responses to P. gingivalis in mice are restricted by H-2 haplotype.
在用牙龈卟啉单胞菌菌毛和脂质体中的佐剂GM - 53经口免疫的各种品系小鼠中，发现BALB/c和DBA/2小鼠（H - 2d）对菌毛是高反应者，CBA/J和C3H小鼠（H - 2k）是中等反应者，而C57BL/6小鼠在血清IgG和唾液IgA反应方面是低反应者。此外，使用显示不同H - 2单倍型的B10背景的同源小鼠检测体液免疫反应，结果显示B10.D2小鼠（H - 2d），其次是B10.BR（H - 2k），对菌毛的抗原刺激反应良好，而C57BL/10小鼠（B10，H - 2b）对菌毛是低反应者。发现BALB/c和C57BL/6小鼠之间的杂交种表现出低反应者的表型。因此，小鼠对牙龈卟啉单胞菌的体液免疫反应受H - 2单倍型限制。
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