用麻风分枝杆菌免疫的近交系小鼠对酚糖脂I的抗体反应。
Antibody response to phenolic glycolipid I in inbred mice immunized with Mycobacterium leprae.
作者信息
Teuscher C, Yanagihara D, Brennan P J, Koster F T, Tung K S
出版信息
Infect Immun. 1985 May;48(2):474-9. doi: 10.1128/iai.48.2.474-479.1985.
Abstract
The level of circulating antibody to phenolic glycolipid I of Mycobacterium leprae was determined in 18 inbred strains of mice after immunization with M. leprae organisms. By using a solid-phase radioimmunoassay with phenolic glycolipid I as test antigen, a continuous distribution of antibody levels ranging from high to low was observed. The level was found to be controlled by multiple genes, including both H-2 complex- and Igh allotype complex-linked genes. Low antibody response to phenolic glycolipid I was shown to be inherited as a dominant trait in three combinations of high X low responder F1 progeny.
摘要
在用麻风杆菌免疫后，测定了18个近交系小鼠中抗麻风杆菌酚糖脂I循环抗体的水平。通过使用以酚糖脂I为检测抗原的固相放射免疫测定法，观察到抗体水平呈从高到低的连续分布。发现该水平受多个基因控制，包括与H-2复合体和免疫球蛋白同种异型复合体相关的基因。在高反应者与低反应者F1代的三种组合中，对酚糖脂I的低抗体反应显示为显性遗传性状。
相似文献
1
Antibody response to phenolic glycolipid I in inbred mice immunized with Mycobacterium leprae.用麻风分枝杆菌免疫的近交系小鼠对酚糖脂I的抗体反应。
Infect Immun. 1985 May;48(2):474-9. doi: 10.1128/iai.48.2.474-479.1985.
2
Strain variations in the murine cellular immune response to the phenolic glycolipid I antigen of Mycobacterium leprae.小鼠对麻风分枝杆菌酚糖脂I抗原细胞免疫反应中的菌株差异。
Infect Immun. 1986 Feb;51(2):495-500. doi: 10.1128/iai.51.2.495-500.1986.
3
Armadillo IgG and IgM antibody responses to phenolic glycolipid-I during experimental infection with M. leprae.犰狳在麻风分枝杆菌实验性感染期间对酚糖脂-I的IgG和IgM抗体反应。
Int J Lepr Other Mycobact Dis. 1988 Sep;56(3):422-7.
4
Humans respond predominantly with IgM immunoglobulin to the species-specific glycolipid of Mycobacterium leprae.人类主要以IgM免疫球蛋白对麻风分枝杆菌的种特异性糖脂作出反应。
J Infect Dis. 1984 Jun;149(6):870-3. doi: 10.1093/infdis/149.6.870.
5
Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.麻风分枝杆菌酚糖脂I的血清学特异性及其在麻风病血清诊断中的应用。
Infect Immun. 1983 Sep;41(3):1077-83. doi: 10.1128/iai.41.3.1077-1083.1983.
6
7
Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.麻风分枝杆菌的酚糖脂1可引起非特异性炎症，但对小鼠的细胞介导反应无影响。
Infect Immun. 1984 Dec;46(3):802-8. doi: 10.1128/iai.46.3.802-808.1984.
8
Immunity to leprosy. II. Genetic control of murine T cell proliferative responses to Mycobacterium leprae.麻风免疫。II. 小鼠T细胞对麻风分枝杆菌增殖反应的遗传控制。
J Immunol. 1985 Oct;135(4):2824-8.
9
10
Serodiagnosis of leprosy: relationships between antibodies to Mycobacterium leprae phenolic glycolipid I and protein antigens.麻风病的血清学诊断：抗麻风分枝杆菌酚糖脂I抗体与蛋白质抗原之间的关系
J Clin Microbiol. 1986 Dec;24(6):917-21. doi: 10.1128/jcm.24.6.917-921.1986.
引用本文的文献
1
IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.IgE 免疫复合物刺激过敏性气道炎症小鼠模型中肺肥大细胞祖细胞的增加。
PLoS One. 2011;6(5):e20261. doi: 10.1371/journal.pone.0020261. Epub 2011 May 19.
2
Strain variations in the murine cellular immune response to the phenolic glycolipid I antigen of Mycobacterium leprae.小鼠对麻风分枝杆菌酚糖脂I抗原细胞免疫反应中的菌株差异。
Infect Immun. 1986 Feb;51(2):495-500. doi: 10.1128/iai.51.2.495-500.1986.
3
Immunological study of the defined constituents of mycobacteria.分枝杆菌特定成分的免疫学研究。
Springer Semin Immunopathol. 1988;10(4):279-300. doi: 10.1007/BF02053841.
4
Control by H-2 genes of murine antibody responses to protein antigens of Mycobacterium tuberculosis.H-2基因对小鼠针对结核分枝杆菌蛋白质抗原的抗体反应的控制
Immunology. 1986 Nov;59(3):329-32.
5
Immune response gene regulation of the humoral immune response to Porphyromonas gingivalis fimbriae in mice.小鼠对牙龈卟啉单胞菌菌毛体液免疫反应的免疫反应基因调控
Immunology. 1991 Oct;74(2):362-4.
本文引用的文献
1
Hereditary Characteristic that Varies Among Isolates of Mycobacterium leprae.麻风分枝杆菌分离株之间存在遗传特征差异。
Infect Immun. 1971 Jan;3(1):121-6. doi: 10.1128/iai.3.1.121-126.1971.
2
A simple radioimmunoassay to determine binding of antibodies to lipid antigens.一种用于测定抗体与脂质抗原结合的简单放射免疫测定法。
J Immunol Methods. 1980;38(1-2):85-93. doi: 10.1016/0022-1759(80)90333-6.
3
The immunology of leprosy: speculations on the leprosy spectrum.麻风病的免疫学：关于麻风病谱的推测
Rev Infect Dis. 1981 May-Jun;3(3):422-69. doi: 10.1093/clinids/3.3.422.
4
A novel phenolic glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity.一种来自麻风分枝杆菌的新型酚糖脂，可能与免疫原性和致病性有关。
J Bacteriol. 1981 Sep;147(3):728-35. doi: 10.1128/jb.147.3.728-735.1981.
5
Evidence for species-specific lipid antigens in Mycobacterium leprae.麻风分枝杆菌中物种特异性脂质抗原的证据。
Int J Lepr Other Mycobact Dis. 1980 Dec;48(4):382-7.
6
Delineation of a human T cell subset responsible for lepromin-induced suppression in leprosy patients.确定麻风病患者中负责麻风菌素诱导抑制作用的人类T细胞亚群。
J Immunol. 1980 Sep;125(3):1183-8.
7
Significance of antibody studies in leprosy and experimental models of the disease.麻风病抗体研究及其疾病实验模型的意义
Int J Lepr Other Mycobact Dis. 1982 Sep;50(3):342-50.
8
Serological activity of purified glycolipid from Mycobacterium leprae.麻风分枝杆菌纯化糖脂的血清学活性
Int J Lepr Other Mycobact Dis. 1982 Jun;50(2):220-1.
9
Zotero 插件