用麻风分枝杆菌免疫的近交系小鼠对酚糖脂I的抗体反应。
Antibody response to phenolic glycolipid I in inbred mice immunized with Mycobacterium leprae.
作者信息
Teuscher C, Yanagihara D, Brennan P J, Koster F T, Tung K S
出版信息
Infect Immun. 1985 May;48(2):474-9. doi: 10.1128/iai.48.2.474-479.1985.
Abstract
The level of circulating antibody to phenolic glycolipid I of Mycobacterium leprae was determined in 18 inbred strains of mice after immunization with M. leprae organisms. By using a solid-phase radioimmunoassay with phenolic glycolipid I as test antigen, a continuous distribution of antibody levels ranging from high to low was observed. The level was found to be controlled by multiple genes, including both H-2 complex- and Igh allotype complex-linked genes. Low antibody response to phenolic glycolipid I was shown to be inherited as a dominant trait in three combinations of high X low responder F1 progeny.
摘要
在用麻风杆菌免疫后，测定了18个近交系小鼠中抗麻风杆菌酚糖脂I循环抗体的水平。通过使用以酚糖脂I为检测抗原的固相放射免疫测定法，观察到抗体水平呈从高到低的连续分布。发现该水平受多个基因控制，包括与H-2复合体和免疫球蛋白同种异型复合体相关的基因。在高反应者与低反应者F1代的三种组合中，对酚糖脂I的低抗体反应显示为显性遗传性状。
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