Suzen Sibel
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandogan, Ankara, Turkey.
Comb Chem High Throughput Screen. 2006 Jul;9(6):409-19. doi: 10.2174/138620706777698553.
Melatonin is known for its radical scavenger activity, which is related to its ability to protect cells from different kinds of oxidative stress. Oxidative stress has been implicated in the development of neurodegenerative diseases like Parkinson, Alzheimer's disease, Huntington's disease, epileptic seizures, stroke, and as a contributor to aging and some cancer types. The antioxidant properties of melatonin include scavenging free radicals and the regulation of the activity and expression of antioxidant and pro-oxidant enzymes. Due to its free radical scavenger and antioxidant properties, multiple melatonin-related compounds such as melatonin metabolites and synthetic analogues are under investigation to determine which exhibit the highest activity with the lowest side effects. This review addresses recent studies with melatonin and related compounds.
褪黑素以其自由基清除活性而闻名，这与其保护细胞免受各种氧化应激的能力有关。氧化应激与帕金森病、阿尔茨海默病、亨廷顿病、癫痫发作、中风等神经退行性疾病的发展有关，并且是衰老和某些癌症类型的一个促成因素。褪黑素的抗氧化特性包括清除自由基以及对抗氧化酶和促氧化酶的活性与表达的调节。由于其自由基清除和抗氧化特性，多种与褪黑素相关的化合物，如褪黑素代谢物和合成类似物，正在进行研究，以确定哪种化合物具有最高活性且副作用最小。本综述阐述了关于褪黑素及相关化合物的最新研究。
