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使用吸入性糖皮质激素治疗13例犬呼吸道疾病

Management of 13 cases of canine respiratory disease using inhaled corticosteroids.

作者信息

Bexfield N H, Foale R D, Davison L J, Watson P J, Skelly B J, Herrtage M E

机构信息

Department of Veterinary Medicine, Queen's Veterinary School Hospital, University of Cambridge, UK.

出版信息

J Small Anim Pract. 2006 Jul;47(7):377-82. doi: 10.1111/j.1748-5827.2006.00028.x.

Abstract

OBJECTIVES

To determine the value of inhaled corticosteroids in the management of chronic inflammatory airway disease in dogs.

METHODS

Medical records of dogs that were presented for the investigation of respiratory disease were reviewed retrospectively. Criteria for inclusion were knowledge of previous medical treatment including side effects, diagnosis of the underlying disease, use of inhaled corticosteroids and at least two-months follow-up data.

RESULTS

Thirteen dogs that fulfilled the criteria were identified. Ten dogs were diagnosed with chronic bronchitis and three with eosinophilic bronchopneumopathy. Four dogs had not previously received corticosteroid treatment for their respiratory disease, and all these showed a reduction or a resolution of clinical signs without obvious side effects after inhaled corticosteroid therapy. Nine dogs had previously received oral or parenteral corticosteroids for treatment of their respiratory disease, and all had exhibited side effects. Five of these dogs were treated with inhaled corticosteroids alone, and all exhibited an improvement in clinical signs without observable side effects. The remaining four dogs were treated with a combination of inhaled and oral corticosteroids, and all showed improvement in clinical signs and reduction in side effects. Inhaled medication was well tolerated in all dogs.

CLINICAL SIGNIFICANCE

Inhaled corticosteroids were used for the management of chronic bronchitis and eosinophilic bronchopneumopathy in 13 dogs, and these may have the advantage of reducing side effects associated with oral corticosteroids.

摘要

目的

确定吸入性皮质类固醇在犬慢性炎症性气道疾病治疗中的价值。

方法

回顾性分析因呼吸道疾病接受检查的犬只的病历。纳入标准包括了解既往治疗情况(包括副作用)、基础疾病诊断、吸入性皮质类固醇的使用以及至少两个月的随访数据。

结果

确定了13只符合标准的犬。10只犬被诊断为慢性支气管炎,3只患有嗜酸性支气管肺炎。4只犬此前未因呼吸道疾病接受皮质类固醇治疗,吸入性皮质类固醇治疗后,所有这些犬的临床症状均减轻或消失,且无明显副作用。9只犬此前曾接受口服或胃肠外皮质类固醇治疗呼吸道疾病,均出现了副作用。其中5只犬仅接受吸入性皮质类固醇治疗,所有犬的临床症状均有改善,且无明显副作用。其余4只犬接受吸入性和口服皮质类固醇联合治疗,所有犬的临床症状均有改善,副作用减少。所有犬对吸入性药物耐受性良好。

临床意义

吸入性皮质类固醇用于治疗13只犬的慢性支气管炎和嗜酸性支气管肺炎,可能具有减少与口服皮质类固醇相关副作用的优势。

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