Hsieh Brisa M, Beets Alicia K
Internal Medicine, Southern Arizona Veterinary Specialty and Emergency Center, Tucson, AZ, United States.
Internal Medicine, MedVet Medical and Cancer Centers for Pets, Metairie, LA, United States.
Front Vet Sci. 2020 Jan 21;6:513. doi: 10.3389/fvets.2019.00513. eCollection 2019.
Cough is one of the most common complaints in human medicine. In veterinary medicine cough is equally frequent and plays a significant role in an owner's perception of their pet's quality of life. In human and veterinary medicine, therapy for chronic cough is often ineffective. The complexity of the cough pathway and species differences have made it difficult to develop an effective antitussive agent for veterinary patients. The few effective antitussive agents currently available are associated with significant adverse effects. Fortunately, several promising drugs currently being studied in human clinical trials may offer options for use of novel antitussive therapies in small animal patients. This article reviews current understanding about cough pathophysiology, diagnostic strategies used to uncover underlying etiology of cough, and examines available options for controlling cough, including novel antitussive therapies used in human medicine.
咳嗽是人类医学中最常见的病症之一。在兽医学中，咳嗽同样频发，并且在主人对其宠物生活质量的认知中起着重要作用。在人类和兽医学中，慢性咳嗽的治疗往往效果不佳。咳嗽通路的复杂性和物种差异使得开发一种有效的兽用镇咳药变得困难。目前可用的少数有效镇咳药都伴有显著的不良反应。幸运的是，目前正在人类临床试验中研究的几种有前景的药物可能为小动物患者提供新型镇咳疗法的使用选择。本文综述了目前对咳嗽病理生理学的认识、用于揭示咳嗽潜在病因的诊断策略，并探讨了控制咳嗽的可用选择，包括人类医学中使用的新型镇咳疗法。
