Forsberg E, Soop M, Thörne A
Department of Anaesthesiology, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Stockholm, Sweden.
Clin Nutr. 1993 Oct;12(5):253-60. doi: 10.1016/0261-5614(93)90042-3.
Nutrient-induced thermogenesis was studied in eight patients with severe nutritional depletion and multiple organ failure after abdominal surgery. Energy expenditure (EE) and RQ were recorded continuously over a period of 4 days. On each study day balanced total parenteral nutrition was administered during a period of approximately 16 h, followed by a period of low-energy glucose infusion. The total energy supply was in the order of 110% of the measured EE and the supply of glucose, fat and amino-acids was 2.6 +/- 0.4, 2.6 +/- 0.2 and 0.84 +/- 0.2 kJ x kg BW(-1) x h(-1) (mean +/- SD), respectively. The nutrient-induced thermogenesis, expressed as the rise in EE in percent of the energy content of the administered nutrients, was approximately 5%, which appears to be lower than previously observed in healthy individuals. A plateau in energy expenditure was reached after 6-8 h in response to parenteral nutrition. It is hypothesized that this plateau reflects the oxidative capacity and thus may be used as a guideline for nutritional therapy.
对8例腹部手术后出现严重营养消耗和多器官功能衰竭的患者进行了营养诱导产热的研究。在4天的时间内持续记录能量消耗（EE）和呼吸商（RQ）。在每个研究日，在大约16小时的时间段内给予平衡的全胃肠外营养，随后是低能量葡萄糖输注期。总能量供应约为测得的EE的110%，葡萄糖、脂肪和氨基酸的供应量分别为2.6±0.4、2.6±0.2和0.84±0.2 kJ·kg体重-1·h-1（平均值±标准差）。营养诱导产热以EE的升高占所给予营养素能量含量的百分比表示，约为5%，这似乎低于先前在健康个体中观察到的水平。胃肠外营养后6-8小时达到能量消耗平台期。据推测，这个平台期反映了氧化能力，因此可作为营养治疗的指导。
