King R F, McMahon M J, Almond D J
Clin Sci (Lond). 1986 Jul;71(1):31-9. doi: 10.1042/cs0710031.
This study was designed to investigate the thermogenic effect of intravenously administered nutrition with glucose (given a fixed nitrogen intake of 12.5 g daily as amino acids) as the principal source of energy. The protocol was designed so that each patient received their energy intake in five consecutive periods of 3 days with intakes ranging from 6650 to 17,100 kJ/day with increments or decrements of 2600 kJ. Thermogenesis from administered glucose was evident between levels of energy supply of 6650 kJ/day and 17,100 kJ/day. The progressive rise in oxygen consumption and carbon dioxide production accounted for a total of 31% of the additional glucose which was administered. The net rate of fat synthesis from glucose reached a maximum 147 g/day at an energy supply of 14,500 kJ/day. This study suggests that both fat synthesis and the associated obligatory thermogenesis is the main component of diet-induced thermogenesis in response to glucose intakes in excess of 150 kJ day-1 kg-1. If the energy cost of fat synthesis (fat associated obligatory thermogenesis) is taken to be 22% of the total energy of the increase in glucose supplied, then only 9% (31-22%) of the glucose can be accounted for by adaptive thermogenesis.
本研究旨在探讨以葡萄糖作为主要能量来源的静脉营养（每日给予固定氮摄入量12.5克氨基酸）的产热效应。研究方案设计为，每位患者在连续5个3天周期内接受能量摄入，摄入量范围为6650至17100千焦/天，每次增减2600千焦。在6650千焦/天至17100千焦/天的能量供应水平之间，给予葡萄糖后的产热明显。耗氧量和二氧化碳生成量的逐步增加占额外给予葡萄糖总量的31%。在能量供应为14500千焦/天时，葡萄糖合成脂肪的净速率达到最大值147克/天。本研究表明，脂肪合成和相关的 obligatory 产热是饮食诱导产热的主要组成部分，以应对每日每千克体重超过150千焦的葡萄糖摄入量。如果脂肪合成的能量成本（与脂肪相关的 obligatory 产热）被视为所供应葡萄糖增加总量能量的22%，那么适应性产热仅能解释9%（31%-22%）的葡萄糖。
