Field Hugh J, Biswas Subhajit, Mohammad Islam T
Centre for Veterinary Science, Cambridge University Veterinary School, Madingley Road, Cambridge CB3 0ES, UK.
Antiviral Res. 2006 Sep;71(2-3):127-33. doi: 10.1016/j.antiviral.2006.03.018. Epub 2006 Jun 27.
This short review considers how the human herpesviruses were among the first viruses to be effectively treated by means of antiviral therapy although the ability of alphaherpsviruses to establish neuronal latency with reactivation remains the major obstacle to achieving a cure. Laboratory animals played an essential role in the development of herpes antivirals including our understanding of the complexity of the neurological infection in relation to chemotherapy. The existence of natural herpesvirus infections in domestic species also contributes to our understanding of latency and reactivation relevant to antiviral therapy although the use of antivirals to treat or prevent virus infections in veterinary species has been minimal, to date. The review briefly focuses on herpes infections in the horse and cat where some progress has already been achieved in the veterinary antiviral field.
这篇简短的综述探讨了人类疱疹病毒如何成为最早通过抗病毒疗法得到有效治疗的病毒之一，尽管甲型疱疹病毒建立神经元潜伏并重新激活的能力仍然是实现治愈的主要障碍。实验动物在疱疹抗病毒药物的研发中发挥了重要作用，包括帮助我们理解与化疗相关的神经感染的复杂性。家养动物中自然存在的疱疹病毒感染也有助于我们理解与抗病毒治疗相关的潜伏和重新激活，尽管迄今为止，在兽医领域使用抗病毒药物治疗或预防病毒感染的情况还很少。这篇综述简要聚焦于马和猫的疱疹感染，在兽医抗病毒领域已经在这方面取得了一些进展。
