Gans Rijk O B
University Medical Center Groningen, Hanzeplein 1 9700 RB, Groningen, The Netherlands.
Med Clin North Am. 2006 Jul;90(4):573-91. doi: 10.1016/j.mcna.2006.05.002.
This article introduces the metabolic syndrome as a clinical phenotype with consequences for diagnosis and treatment that go beyond the different clinical specialties involved. A life-course approach is suggested as a means of understanding the complex interrelations between the metabolic syndrome, depression, and cardiovascular disease. Pathophysiologic mechanisms that these conditions share are discussed in detail. These considerations provide arguments for a more integrative approach to patients in general that surpass the current disease-centered services such as endocrinology, psychiatry, and cardiology.
本文介绍了代谢综合征这一临床表型，其对诊断和治疗的影响超出了所涉及的不同临床专业范畴。建议采用生命历程方法来理解代谢综合征、抑郁症和心血管疾病之间复杂的相互关系。详细讨论了这些病症共有的病理生理机制。这些考量为总体上对患者采取更综合的方法提供了依据，这种方法超越了当前以内分泌学、精神病学和心脏病学等以疾病为中心的服务模式。
