糖尿病是一种血管疾病：内皮功能障碍在糖尿病心血管疾病病理生理学中的作用。

Diabetes is a vascular disease: the role of endothelial dysfunction in pathophysiology of cardiovascular disease in diabetes.

作者信息

Deedwania Prakash C

机构信息

Division of Cardiology, Department of Medicine, VA Central California Health Care Systemn, University of California-San Francisco Program, Fresno 93703, USA.

出版信息

Cardiol Clin. 2004 Nov;22(4):505-9, v. doi: 10.1016/j.ccl.2004.07.001.

DOI:10.1016/j.ccl.2004.07.001

PMID:15501619

Abstract

Diabetes is a vascular disease. Endothelial dysfunction is the initial process in vascular manifestations of diabetes mellitus (DM). There are multiple pathways involved in the pathophysiologic process related to endothelial dysfunction in DM. Most of these abnormalities occur secondary to insulin resistance. In this article the role of insulin, glucose,dyslipidemia, oxidative stress and various cellular mechanisms related to endothelial dys-function in diabetes are discussed in detail.

摘要

糖尿病是一种血管疾病。内皮功能障碍是糖尿病（DM）血管表现的初始过程。糖尿病中与内皮功能障碍相关的病理生理过程涉及多种途径。这些异常大多继发于胰岛素抵抗。本文详细讨论了胰岛素、葡萄糖、血脂异常、氧化应激以及糖尿病中与内皮功能障碍相关的各种细胞机制的作用。