Hawkins Richard A, Simpson Ian A, Mokashi Ashwini, Viña Juan R
Department of Physiology and Biophysics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064-3095, USA.
FEBS Lett. 2006 Aug 7;580(18):4382-6. doi: 10.1016/j.febslet.2006.06.097. Epub 2006 Jul 10.
Regulation of Na(+)-dependent glutamate transport was studied in isolated luminal and abluminal plasma membranes derived from the bovine blood-brain barrier. Abluminal membranes have Na(+)-dependent glutamate transporters while luminal membranes have facilitative transporters. This organization allows glutamate to be actively removed from brain. gamma-Glutamyl transpeptidase, the first enzyme of the gamma-glutamyl cycle (GGC), is on the luminal membrane. Pyroglutamate (oxoproline), an intracellular product of GGC, stimulated Na(+)-dependent transport of glutamate by 46%, whereas facilitative glutamate uptake in luminal membranes was inhibited. This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain.
在源自牛血脑屏障的分离的管腔和管腔外质膜中研究了钠依赖性谷氨酸转运的调节。管腔外质膜具有钠依赖性谷氨酸转运体，而管腔质膜具有易化转运体。这种组织结构使得谷氨酸能够从脑内被主动清除。γ-谷氨酰转肽酶是γ-谷氨酰循环（GGC）的首个酶，位于管腔质膜上。焦谷氨酸（氧代脯氨酸）是GGC的一种细胞内产物，它使钠依赖性谷氨酸转运增加了46%，而管腔质膜中谷氨酸的易化摄取则受到抑制。GGC与谷氨酸转运体之间的这种关系可能是加速谷氨酸从脑内清除的调节机制的一部分。
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