对中风后抑郁症（PSD）患者生化扰动的代谢组学研究。
A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD).
作者信息
Ding Xinghua, Liu Ruoxu, Li Wenkai, Ni Hengjia, Liu Yong, Wu Dandan, Yang Shuguang, Liu Jing, Xiao Bo, Liu Shaojun
机构信息
State Key Laboratory of Proteomics and Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing, 100850, China.
State Key Laboratory of Medical Genetics and School of Life Science, Central South University, 110 Xiangya Road, Changsha, 410078, China.
出版信息
Metab Brain Dis. 2016 Apr;31(2):279-87. doi: 10.1007/s11011-015-9748-z. Epub 2015 Nov 5.
A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.
进行了一项基于气相色谱/质谱联用（GC/MS）和多元统计分析的代谢组学研究，纳入了28例中风后抑郁（PSD）患者、27例中风后无抑郁（PSND）患者和33名健康受试者，以研究他们血浆样本中的生化扰动。该研究结果表明，PSD患者有独特的代谢谱。七种哨兵代谢物在PSD患者血液中显示出明显的扰动。代谢组学方法的引入可能为PSD提供新的代谢组学见解以及用于PSD分类的哨兵代谢物。
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