Kureshi Faraz, Kalaaji Amer N, Halvorson Larry, Pittelkow Mark R, Davis Mark D P
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
J Am Acad Dermatol. 2006 Aug;55(2):328-31. doi: 10.1016/j.jaad.2005.07.041.
Transitional cell carcinoma of the bladder is frequently treated with intravesical injection of immunotherapeutic (eg, BCG) or chemotherapeutic (eg, mitomycin C) agents. The aim of this study was to report cutaneous complications of intravesical therapy in 2 patients with transitional cell carcinoma of the bladder. A 69-year-old man had an ulceration at the base of the penis and papules involving the glans penis 1 month after injection of intravesical BCG. Biopsy findings showed granulomatous inflammation with foci of dermal necrosis suggestive of a BCG-related granulomatous reaction. The second patient was a 73-year-old man with penile gangrene. Erythema involving his penis and perineum had developed within 24 hours after intravesical administration of mitomycin C, which spilled onto his perineum during catheter removal. The resulting penile gangrene required penectomy 3 months after the injection. Mitomycin C patch testing showed a clear allergic contact reaction. Dermatologists should be aware of these potential cutaneous complications.
膀胱移行细胞癌常采用膀胱内注射免疫治疗药物（如卡介苗）或化疗药物（如丝裂霉素C）进行治疗。本研究的目的是报告2例膀胱移行细胞癌患者膀胱内治疗后的皮肤并发症。一名69岁男性在膀胱内注射卡介苗1个月后，阴茎根部出现溃疡，龟头出现丘疹。活检结果显示肉芽肿性炎症，伴有真皮坏死灶，提示卡介苗相关的肉芽肿反应。第二名患者是一名73岁男性，患有阴茎坏疽。在膀胱内注射丝裂霉素C后24小时内，其阴茎和会阴部出现红斑，在拔除导尿管时丝裂霉素C洒到了会阴部。注射3个月后，由此导致的阴茎坏疽需要进行阴茎切除术。丝裂霉素C斑贴试验显示明显的过敏性接触反应。皮肤科医生应意识到这些潜在的皮肤并发症。
