• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用丝裂霉素C进行腹腔热灌注化疗后阴囊壁坏死：病例报告及文献复习

Scrotal wall necrosis after hipec using mitomycin-c: Case report and review of the literature.

作者信息

El Halabieh Mriam Attalla, Lodoli Claudio, Ferracci Federica, Santullo Francesco, Pacelli Fabio, Foschi Nazario

机构信息

Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Italy.

Surgical Unit of Peritoneum and Retroperitoneum Surgery, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Italy.

出版信息

Int J Surg Case Rep. 2025 Jan;126:110797. doi: 10.1016/j.ijscr.2024.110797. Epub 2025 Jan 1.

DOI:10.1016/j.ijscr.2024.110797
PMID:39753069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11755072/
Abstract

INTRODUCTION

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a current treatment option for peritoneal carcinosis (PC) after cytoreductive surgery (CRS). Genital skin alterations are rare complications reported variously after HIPEC using Mitomycin-C.

PRESENTATION OF CASE

A 42-year-old man with a diagnosis of stage IV colorectal cancer underwent CRS and HIPEC using mitomycin-C. On postoperative day 75, he developed scrotal wall necrosis not responding to any medical treatment. After he underwent surgery to remove the necrotic tissue and primarily suture the scrotal wound with success.

DISCUSSION

Genital skins disorders are rarely drugs-related effects and few cases after HIPEC using Mitomycin-C are reported in literature. The most accepted hypothesis to explain the occurrence of scrotal ulcers after CRS and HIPEC is the extravasation reaction to Mitomycin-C that inhibits wound healing and induces skin necrosis.

CONCLUSION

Correct diagnosis and immediate surgical debridement are the preferable management.

摘要

引言

热灌注化疗（HIPEC）是目前减瘤手术（CRS）后腹膜癌转移（PC）的一种治疗选择。使用丝裂霉素-C进行HIPEC治疗后，生殖器皮肤改变是罕见的并发症，已有多种相关报道。

病例介绍

一名42岁诊断为IV期结直肠癌的男性接受了CRS及使用丝裂霉素-C的HIPEC治疗。术后第75天，他出现阴囊壁坏死，任何药物治疗均无效。之后他接受了手术，成功切除坏死组织并一期缝合阴囊伤口。

讨论

生殖器皮肤疾病很少是药物相关效应，文献中报道的使用丝裂霉素-C进行HIPEC治疗后的病例很少。解释CRS和HIPEC后阴囊溃疡发生的最被认可的假说是丝裂霉素-C的外渗反应，它会抑制伤口愈合并导致皮肤坏死。

结论

正确诊断和立即手术清创是较好的处理方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc78/11755072/75f4c03d92f8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc78/11755072/94ec084defa2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc78/11755072/75f4c03d92f8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc78/11755072/94ec084defa2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc78/11755072/75f4c03d92f8/gr2.jpg

相似文献

1
Scrotal wall necrosis after hipec using mitomycin-c: Case report and review of the literature.使用丝裂霉素C进行腹腔热灌注化疗后阴囊壁坏死：病例报告及文献复习
Int J Surg Case Rep. 2025 Jan;126:110797. doi: 10.1016/j.ijscr.2024.110797. Epub 2025 Jan 1.
2
Delayed genital necrosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with Mitomycin-C.细胞减灭术和含丝裂霉素 C 的腹腔热灌注化疗后生殖器延迟性坏死。
Eur J Surg Oncol. 2021 Sep;47(9):2352-2357. doi: 10.1016/j.ejso.2021.04.002. Epub 2021 Apr 20.
3
[Efficacy of 1 384 cases of peritoneal carcinomatosis underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy].1384例腹膜癌病患者接受细胞减灭术加腹腔内热灌注化疗的疗效
Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Mar 25;24(3):230-239. doi: 10.3760/cma.j.cn.441530-20201110-00603.
4
Scrotal Necrosis Following Heated Intra-peritoneal Chemotherapy: Case Report and Review of the Literature.热灌注化疗后阴囊坏死：病例报告及文献复习
Cureus. 2021 Dec 23;13(12):e20638. doi: 10.7759/cureus.20638. eCollection 2021 Dec.
5
Systematic review of published literature on oxaliplatin and mitomycin C as chemotherapeutic agents for hyperthermic intraperitoneal chemotherapy in patients with peritoneal metastases from colorectal cancer.奥沙利铂和丝裂霉素 C 作为腹腔热灌注化疗治疗结直肠癌细胞腹膜转移患者的化疗药物的文献系统评价。
Crit Rev Oncol Hematol. 2019 Oct;142:119-129. doi: 10.1016/j.critrevonc.2019.06.014. Epub 2019 Jul 9.
6
Cytoreductive surgery and mitomycin C hyperthermic intraperitoneal chemotherapy with CO recirculation (HIPEC-CO) for colorectal cancer peritoneal metastases: analysis of short-term outcomes.细胞减灭术和丝裂霉素 C 腹腔高温化疗联合 CO 再循环（HIPEC-CO）治疗结直肠癌腹膜转移：短期疗效分析。
Updates Surg. 2021 Aug;73(4):1443-1448. doi: 10.1007/s13304-021-01034-2. Epub 2021 Mar 29.
7
Diagnostic Laparoscopy in Patients With Peritoneal Carcinomatosis Is Safe and Does Not Delay Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy.腹腔镜检查在腹膜转移癌患者中是安全的，不会延迟含热灌注化疗的细胞减灭术。
Am Surg. 2022 Apr;88(4):698-703. doi: 10.1177/00031348211048819. Epub 2021 Nov 3.
8
Safety of intraperitoneal Mitomycin C versus intraperitoneal oxaliplatin in patients with peritoneal carcinomatosis of colorectal cancer undergoing cytoreductive surgery and HIPEC.结直肠癌腹膜转移患者行细胞减灭术和 HIPEC 术中腹腔内丝裂霉素 C 与奥沙利铂安全性的比较。
Eur J Surg Oncol. 2018 Feb;44(2):220-227. doi: 10.1016/j.ejso.2017.10.216. Epub 2017 Nov 15.
9
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy With Mitomycin C Used for Colorectal Peritoneal Carcinomatosis.丝裂霉素C用于结直肠癌腹膜转移癌的细胞减灭术和腹腔内热灌注化疗
Ann Coloproctol. 2020 Feb;36(1):22-29. doi: 10.3393/ac.2019.04.30. Epub 2020 Feb 29.
10
Peritoneal carcinomatosis in colorectal cancer: Defining predictive factors for successful cytoreductive surgery and hyperthermic intraperitoneal chemotherapy - A pilot study.结直肠癌腹膜转移癌：确定减瘤手术及腹腔热灌注化疗成功的预测因素——一项初步研究
J Egypt Natl Canc Inst. 2018 Dec;30(4):143-150. doi: 10.1016/j.jnci.2018.10.004. Epub 2018 Nov 22.

本文引用的文献

1
The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2023 指南：更新共识外科病例报告（SCARE）指南。
Int J Surg. 2023 May 1;109(5):1136-1140. doi: 10.1097/JS9.0000000000000373.
2
Rare, but severe: Delayed genitoscrotal necrosis after HIPEC with Mitomycin-C.
Eur J Surg Oncol. 2022 Mar;48(3):703-704. doi: 10.1016/j.ejso.2021.12.013. Epub 2021 Dec 16.
3
Delayed genital necrosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with Mitomycin-C.细胞减灭术和含丝裂霉素 C 的腹腔热灌注化疗后生殖器延迟性坏死。
Eur J Surg Oncol. 2021 Sep;47(9):2352-2357. doi: 10.1016/j.ejso.2021.04.002. Epub 2021 Apr 20.
4
Full thickness penile skin necrosis following HIPEC: Case report and literature review.腹腔热灌注化疗后阴茎全层皮肤坏死：病例报告及文献综述
Urol Case Rep. 2020 Oct 6;34:101430. doi: 10.1016/j.eucr.2020.101430. eCollection 2021 Jan.
5
Toxicity profile of chemotherapy agents used in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies.细胞减灭术和腹腔内热灌注化疗治疗腹膜表面恶性肿瘤中使用的化疗药物的毒性特征。
Eur J Surg Oncol. 2020 Apr;46(4 Pt A):577-581. doi: 10.1016/j.ejso.2019.10.032. Epub 2019 Oct 26.
6
Scrotal ulceration: a complication of hyperthermic intraperitoneal chemotherapy and subsequent treatment with dimethyl sulfoxide.
Cutis. 2019 Jul;104(1):E1-E3.
7
Idiopathic scrotal fat necrosis: an unusual cause of scrotal pain.特发性阴囊脂肪坏死：阴囊疼痛的一种罕见病因。
BMJ Case Rep. 2018 Apr 17;2018:bcr-2017-224087. doi: 10.1136/bcr-2017-224087.
8
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of gastrointestinal cancers with peritoneal metastases: Progress toward a new standard of care.细胞减灭术和腹腔热灌注化疗治疗胃肠道癌腹膜转移：迈向新的治疗标准的进展。
Cancer Treat Rev. 2016 Jul;48:42-9. doi: 10.1016/j.ctrv.2016.06.007. Epub 2016 Jun 16.
9
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a review of factors contributing to morbidity and mortality.肿瘤细胞减灭术及腹腔热灌注化疗：对发病和死亡相关因素的综述
J Gastrointest Oncol. 2016 Feb;7(1):99-111. doi: 10.3978/j.issn.2078-6891.2015.100.
10
Scrotal pain and ulceration post HIPEC: a case report.腹腔热灌注化疗术后阴囊疼痛及溃疡：一例报告
J Gastrointest Cancer. 2015 Mar;46(1):60-3. doi: 10.1007/s12029-014-9665-0.