Kleemann D, Kramp B
Universität Rostock, Medizinische Fakultät, Hals-Nasen-Ohren-Klinik und Poliklinik, Otto Körner.
Laryngorhinootologie. 1991 Dec;70(12):686-9. doi: 10.1055/s-2007-998126.
46 patients with progressive tumors in the head and neck region (18 x oropharynx, 13 x hypopharynx, 9 x larynx and 6 x other localization) were treated with a increasing analgetic therapy regimen (WHO schedule) for their cancer pain. The results of the therapy were recorded and controlled with the aid of scale methods. A good result was recorded with the administration of (a) peripheral analgetics on 42% of therapy days and (b) weak nonnarcotic opiates in combination with peripheral analgetic drugs and partially with psychopharmaceuticals (17.5%) on 51% of therapy days. A therapy with strong opiates (regularly in combination) was necessary on 7% of all therapy days. A total of 4848 therapy days have been considered here. The principles and problems of such a stepwise treatment schedule are discussed.
46例头颈部进展期肿瘤患者（18例口咽癌、13例下咽癌、9例喉癌和6例其他部位肿瘤）接受了递增的镇痛治疗方案（世界卫生组织方案）以缓解癌痛。治疗结果通过量表方法进行记录和对照。结果显示，在42%的治疗日，使用（a）外周镇痛药取得了良好效果；在51%的治疗日，使用（b）弱效非麻醉性阿片类药物联合外周镇痛药以及部分联合精神药物（17.5%）取得了良好效果。在所有治疗日中，有7%的时间需要使用强效阿片类药物（通常为联合用药）。此处共考虑了4848个治疗日。本文还讨论了这种逐步治疗方案的原则和问题。
