SWAKK：一个使用滑动窗口替代率分析来检测蛋白质中正选择的网络服务器。
SWAKK: a web server for detecting positive selection in proteins using a sliding window substitution rate analysis.
作者信息
Liang Han, Zhou Weihua, Landweber Laura F
机构信息
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
出版信息
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W382-4. doi: 10.1093/nar/gkl272.
We present a bioinformatic web server (SWAKK) for detecting amino acid sites or regions of a protein under positive selection. It estimates the ratio of non-synonymous to synonymous substitution rates (K(A)/K(S)) between a pair of protein-coding DNA sequences, by sliding a 3D window, or sphere, across one reference structure. The program displays the results on the 3D protein structure. In addition, for comparison or when a reference structure is unavailable, the server can also perform a sliding window analysis on the primary sequence. The SWAKK web server is available at http://oxytricha.princeton.edu/SWAKK/.
我们展示了一个用于检测处于正选择下的蛋白质氨基酸位点或区域的生物信息学网络服务器（SWAKK）。它通过在一个参考结构上滑动一个三维窗口或球体，来估计一对蛋白质编码DNA序列之间非同义替换率与同义替换率的比值（K(A)/K(S)）。该程序会在三维蛋白质结构上显示结果。此外，为了进行比较或在没有参考结构的情况下，服务器还可以对一级序列进行滑动窗口分析。SWAKK网络服务器可在http://oxytricha.princeton.edu/SWAKK/获取。
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