BLAST：用于更好序列分析的改进方法。

Ye Jian, McGinnis Scott, Madden Thomas L

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W6-9. doi: 10.1093/nar/gkl164.

Basic local alignment search tool (BLAST) is a sequence similarity search program. The National Center for Biotechnology Information (NCBI) maintains a BLAST server with a home page at http://www.ncbi.nlm.nih.gov/BLAST/. We report here on recent enhancements to the results produced by the BLAST server at the NCBI. These include features to highlight mismatches between similar sequences, show where the query was masked for low-complexity sequence, and integrate information about the database sequences from the NCBI Entrez system into the BLAST display. Changes to how the database sequences are fetched have also improved the speed of the report generator.

基本局部比对搜索工具（BLAST）是一个序列相似性搜索程序。美国国立生物技术信息中心（NCBI）维护着一个BLAST服务器，其主页为http://www.ncbi.nlm.nih.gov/BLAST/。我们在此报告NCBI的BLAST服务器所产生结果的近期改进。这些改进包括突出显示相似序列之间错配的功能、显示查询序列中因低复杂性序列而被屏蔽的位置，以及将来自NCBI Entrez系统的数据库序列信息整合到BLAST显示中。数据库序列获取方式的改变也提高了报告生成器的速度。