Grau G E, Modlin R L
University of Geneva, Switzerland.
Curr Opin Immunol. 1991 Aug;3(4):480-5. doi: 10.1016/0952-7915(91)90007-n.
The immunological mechanisms that contribute to resistance versus susceptibility to bacterial and parasitic infection are central to the development of improved prophylactic and therapeutic strategies. The delineation of two subsets of CD4+ T cells in the mouse that regulate these responses has provided a tremendous advance in understanding disease pathogenesis. The elucidation of protective immune mechanisms distinct from those that cause tissue damage should lead to the development of appropriate vaccines against these devastating illnesses.
促成对细菌和寄生虫感染产生抗性或易感性的免疫机制，是改进预防和治疗策略发展的核心。对小鼠中调节这些反应的两类CD4 + T细胞亚群的描述，在理解疾病发病机制方面取得了巨大进展。阐明与那些导致组织损伤的机制不同的保护性免疫机制，应能促成针对这些毁灭性疾病的合适疫苗的研发。
