Jones Neil C, Zhi Degui, Raphael Benjamin J
Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W613-6. doi: 10.1093/nar/gkl288.
Multiple sequence alignment programs are an invaluable tool in computational biology. A-Bruijn Alignment (ABA) is a method for multiple sequence alignment that represents an alignment as a directed graph and has proved useful in aligning nucleotide and amino acid sequences that are composed of repeated and shuffled subsequences. AliWABA is a web server that provides tools to generate alignments with ABA, visualize the resulting ABA graphs and extract subsequences from ABA graphs. AliWABA greatly simplifies the problem of analyzing multiple sequences for local similarities that may be reordered, as is common with the domain architectures of proteins. To facilitate the analysis of protein domains, AliWABA provides direct querying of the Conserved Domain Database.
多序列比对程序是计算生物学中一项非常宝贵的工具。A-Bruijn比对（ABA）是一种多序列比对方法，它将比对表示为有向图，并且已证明在比对由重复和重排子序列组成的核苷酸和氨基酸序列时很有用。AliWABA是一个网络服务器，提供使用ABA生成比对、可视化所得ABA图以及从ABA图中提取子序列的工具。AliWABA极大地简化了分析多个序列以查找可能重新排序的局部相似性的问题，这在蛋白质的结构域架构中很常见。为便于分析蛋白质结构域，AliWABA提供对保守结构域数据库的直接查询。
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