Morgenstern Burkhard
Abteilung für Bioinformatik (IMG), Universitat Göttingen, Göttingen, Germany.
Methods Mol Biol. 2014;1079:191-202. doi: 10.1007/978-1-62703-646-7_12.
DIALIGN is a software tool for multiple sequence alignment by combining global and local alignment features. It composes multiple alignments from local pairwise sequence similarities. This approach is particularly useful to discover conserved functional regions in sequences that share only local homologies but are otherwise unrelated. An anchoring option allows to use external information and expert knowledge in addition to primary-sequence similarity alone. The latest version of DIALIGN optionally uses matches to the PFAM database to detect weak homologies. Various versions of the program are available through Göttingen Bioinformatics Compute Server (GOBICS) at http://www.gobics.de/department/software.
DIALIGN是一款通过结合全局和局部比对特征来进行多序列比对的软件工具。它从局部两两序列相似性构建多序列比对。这种方法对于在仅共享局部同源性但其他方面不相关的序列中发现保守功能区域特别有用。一个锚定选项允许除了仅基于一级序列相似性之外，还能使用外部信息和专家知识。DIALIGN的最新版本可选择使用与PFAM数据库的匹配来检测微弱同源性。该程序的各种版本可通过哥廷根生物信息学计算服务器（GOBICS）在http://www.gobics.de/department/software获取。
