使用Clustal系列程序进行多序列比对。
Multiple sequence alignment with the Clustal series of programs.
作者信息
Chenna Ramu, Sugawara Hideaki, Koike Tadashi, Lopez Rodrigo, Gibson Toby J, Higgins Desmond G, Thompson Julie D
机构信息
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
出版信息
Nucleic Acids Res. 2003 Jul 1;31(13):3497-500. doi: 10.1093/nar/gkg500.
Abstract
The Clustal series of programs are widely used in molecular biology for the multiple alignment of both nucleic acid and protein sequences and for preparing phylogenetic trees. The popularity of the programs depends on a number of factors, including not only the accuracy of the results, but also the robustness, portability and user-friendliness of the programs. New features include NEXUS and FASTA format output, printing range numbers and faster tree calculation. Although, Clustal was originally developed to run on a local computer, numerous Web servers have been set up, notably at the EBI (European Bioinformatics Institute) (http://www.ebi.ac.uk/clustalw/).
摘要
Clustal系列程序在分子生物学中被广泛用于核酸和蛋白质序列的多序列比对以及构建系统发育树。这些程序的受欢迎程度取决于多种因素，不仅包括结果的准确性，还包括程序的稳健性、可移植性和用户友好性。新特性包括NEXUS和FASTA格式输出、打印范围编号以及更快的树计算。虽然Clustal最初是为在本地计算机上运行而开发的，但现在已经建立了许多网络服务器，尤其是欧洲生物信息学研究所（EBI）的服务器（http://www.ebi.ac.uk/clustalw/）。
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