一种用于不可切除原发性肝癌的新型局部消融术：电热和电化学疗法对大鼠肝脏的影响
A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver.
作者信息
Xie Lei, Sun Cai-jun, Zhao Shi-fang
机构信息
Department of Head and Neck Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
出版信息
J Zhejiang Univ Sci B. 2006 Aug;7(8):654-9. doi: 10.1631/jzus.2006.B0654.
BACKGROUND
Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver.
METHODS
Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer.
RESULTS
We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was increased in ECT group.
CONCLUSION
ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.
背景
电化学疗法（ECT）已被用于治疗无法切除的肝肿瘤。为了提高其疗效，我们将ECT与电热针（ETN）诱导的热疗相结合（ETECT）。本研究的目的是探讨ETECT对正常大鼠肝脏的破坏作用。
方法
将20只大鼠随机分为4个治疗组（每组n = 5）：对照组、单纯ECT组、单纯热疗组和ETECT组。治疗后，取肝脏切片进行光学显微镜组织学检查，并用测微计测量破坏体积。
结果
我们发现ETECT组的破坏体积最大（P < 0.01）。在ETECT组的阳极和阴极区域均发现凝固性坏死，其周围存在过渡区。仅在ECT组增加电量时才能看到过渡区。
结论
ETECT被证明可增强ECT的破坏作用。本研究为不可切除原发性肝癌的新型局部消融治疗提供了理论和实验依据。
Zotero 插件