Sun Cai-jun, Xie Lei
Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2003 Sep;38(5):351-4.
To explore the anti-tumor effects and the mechanism of a new treatment for Sarcoma180 in mice using both hyperthermia (H) and electrochemical therapy (ECT).
A group of mice with Sarcoma180 (1 cm in diameter) were divided randomly into four groups and given different treatments: Control, ECT alone, H alone and electrothermal & electrochemical therapy (ETECT). The volumes of the tumors were calculated everyday after treatment. The tumor tissues were examined morphologically at 0, 6, 24 and 72 hours after treatment.
The tumors treated with ETECT were completely destroyed, and did not recur within a period of ten days by pathological examination. Results of this group were significantly different with the other groups (P<0.01). However, recurred tumors were found in 6 mice of H group and 5 mice of ECT group, respectively.
Based on the results obtained, ETECT induced by ETECD (D-device) is an effective way to eliminate cancer. It is capable of completely destroying cancer cells in a short time. The rate of Sarcoma180 inhibition is 100%, and malignant cells can't recur. The research provided theoretical and experimental bases for the treatment of oral cancer by a new approach to treat oral cancer.
探讨热疗（H）联合电化学疗法（ECT）对小鼠肉瘤180的抗肿瘤作用及其机制。
将一组直径为1 cm的肉瘤180小鼠随机分为四组，给予不同治疗：对照组、单纯ECT组、单纯H组和电热电化学疗法（ETECT）组。治疗后每天计算肿瘤体积。在治疗后0、6、24和72小时对肿瘤组织进行形态学检查。
接受ETECT治疗的肿瘤完全被破坏，病理检查显示在十天内未复发。该组结果与其他组有显著差异（P<0.01）。然而，H组和ECT组分别有6只和5只小鼠出现肿瘤复发。
根据所得结果，由ETECD（D型设备）诱导的ETECT是一种有效的癌症消除方法。它能够在短时间内完全破坏癌细胞。肉瘤180的抑制率为100%，恶性细胞不会复发。该研究为通过新方法治疗口腔癌提供了理论和实验依据。
