Pardini Ronald S
Department of Biochemistry, University of Nevada, Reno, NV 89557, USA.
Chem Biol Interact. 2006 Aug 25;162(2):89-105. doi: 10.1016/j.cbi.2006.05.012. Epub 2006 May 27.
Nutritional intervention with specific fatty acids depresses tumor growth and enhances tumor responsiveness to chemotherapy. Supplementation of tumors with long chained omega-3 polyunsaturated fatty acids results in enrichment of tumor phospholipid fractions with omega-3 fatty acids resulting in an altered membrane composition and function. Tumors enriched with long chained omega-3 polyunsaturated fatty acids possess membranes with increased fluidity, an elevated unsaturation index, enhanced transport capabilities that results in accumulation of selective anti-cancer agents, increased activity of selected drug activating enzymes, and alteration of signaling pathways important for cancer progression. These nutritionally induced changes in tumor fatty acid composition result in increased sensitivity to chemotherapy, especially in tumor lines that are resistant to chemotherapy and cause specific enhancement of cytotoxicity to tumor cells and protection of normal cells. Pre-disposing tumors to increased chemo-sensitivity through nutritional intervention with specific fatty acids has the potential to improve patient response to chemotherapy with fewer untoward side effects if these pre-clinical findings carry over into a clinical setting.
特定脂肪酸的营养干预可抑制肿瘤生长，并增强肿瘤对化疗的反应性。用长链ω-3多不饱和脂肪酸补充肿瘤会导致肿瘤磷脂组分富含ω-3脂肪酸，从而改变膜的组成和功能。富含长链ω-3多不饱和脂肪酸的肿瘤具有流动性增加、不饱和指数升高、转运能力增强（导致选择性抗癌剂积累）、选定药物激活酶活性增加以及对癌症进展重要的信号通路改变的膜。这些由营养引起的肿瘤脂肪酸组成变化导致对化疗的敏感性增加，尤其是在对化疗耐药的肿瘤细胞系中，并导致对肿瘤细胞的细胞毒性特异性增强以及对正常细胞的保护。如果这些临床前研究结果能应用于临床环境，那么通过特定脂肪酸的营养干预使肿瘤对化疗敏感性增加，有可能改善患者对化疗的反应，且副作用更少。
