Stephenson J A, Al-Taan O, Arshad A, Morgan B, Metcalfe M S, Dennison A R
Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK ; Department of Imaging, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
J Lipids. 2013;2013:261247. doi: 10.1155/2013/261247. Epub 2013 May 16.
Omega-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid, and docosahexaenoic acid have been shown to have multiple beneficial antitumour actions that affect the essential alterations that dictate malignant growth. In this review we explore the putative mechanisms of action of omega-3 polyunsaturated fatty acid in cancer protection in relation to self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion, and how these will hopefully translate from bench to bedside.
ω-3多不饱和脂肪酸，特别是二十碳五烯酸和二十二碳六烯酸，已被证明具有多种有益的抗肿瘤作用，这些作用会影响决定恶性生长的关键改变。在这篇综述中，我们探讨了ω-3多不饱和脂肪酸在癌症预防中与生长信号的自给自足、对生长抑制信号的不敏感、细胞凋亡、无限增殖潜能、持续血管生成和组织侵袭相关的假定作用机制，以及这些机制有望如何从实验室转化到临床应用。
