Ohashi H, Okugawa T, Itoh M
Third Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Acta Endocrinol (Copenh). 1991 Nov;125(5):502-9. doi: 10.1530/acta.0.1250502.
To investigate the relationships between lymphocyte subsets and thyroid function, peripheral blood lymphocytes were analysed with cell surface antigens of activated (HLA-DR+) T, helper T (CD4+ 2H4-, CD4+ 4B4+) and suppressor-inducer T (CD4+ 2H4+, CD4+ 4B4-) cells subsets in 56 patients with Graves' disease, 16 patients with Hashimoto's thyroiditis, 7 patients with typical subacute thyroiditis and 2 patients with the thyrotoxic phase of autoimmune thyroiditis. Both patients with Graves' disease and Hashimoto's thyroiditis had increased percentages of HLA-DR+ T (Ia+ CD3+) cells as well as HLA-DR+ helper-inducer T (Ia+ CD4+) cells, which seemed to be independent of treatments. The percentage of HLA-DR+ suppressor-cytotoxic T (Ia+ CD8+) cells was increased in euthyroid or hypothyroid patients with Graves' disease following treatment, but was normal in hyperthyroid patients. The percentages of Ia+ CD4+ cells and Ia+ CD8+ were also increased in patients with thyroiditis, whereas these abnormal values normalized in the remission phase. These findings suggest that an increase in Ia+ CD4+ cells characteristically occurs during immune system activation in patients with hyperthyroid Graves' disease, Hashimoto's thyroiditis and the thyrotoxic phase of subacute thyroiditis, whereas the activated CD8+ cells in Graves' disease are induced by antithyroidal therapy.
为研究淋巴细胞亚群与甲状腺功能之间的关系，对56例格雷夫斯病患者、16例桥本甲状腺炎患者、7例典型亚急性甲状腺炎患者和2例自身免疫性甲状腺炎甲状腺毒症期患者的外周血淋巴细胞进行分析，检测活化（HLA-DR+）T细胞、辅助性T细胞（CD4+ 2H4-，CD4+ 4B4+）和抑制诱导性T细胞（CD4+ 2H4+，CD4+ 4B4-）亚群的细胞表面抗原。格雷夫斯病患者和桥本甲状腺炎患者的HLA-DR+ T（Ia+ CD3+）细胞以及HLA-DR+辅助诱导性T（Ia+ CD4+）细胞百分比均升高，这似乎与治疗无关。格雷夫斯病甲状腺功能正常或减退患者治疗后HLA-DR+抑制性细胞毒性T（Ia+ CD8+）细胞百分比升高，但甲状腺功能亢进患者该百分比正常。甲状腺炎患者的Ia+ CD4+细胞和Ia+ CD8+细胞百分比也升高，而在缓解期这些异常值恢复正常。这些发现表明，甲状腺功能亢进的格雷夫斯病、桥本甲状腺炎和亚急性甲状腺炎甲状腺毒症期患者在免疫系统激活过程中特征性地出现Ia+ CD4+细胞增加，而格雷夫斯病中活化的CD8+细胞是由抗甲状腺治疗诱导产生的。
