Jaworski Tomasz
Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Cell Mol Biol Lett. 2006;11(1):109-31. doi: 10.2478/s11658-006-0011-9.
The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors which mediates the action of androgens in the development of urogenital structures. AR expression is regulated post-translationally by the ubiquitin/proteasome system. This regulation involves more complex mechanisms than typical degradation. The ubiquitin/proteasome system may regulate AR via mechanisms that do not engage in receptor turnover. Given the critical role of AR in sexual development, this complex regulation is especially important. Deregulation of AR signalling may be a causal factor in prostate cancer development. AR is the main target in prostate cancer therapies. Due to the critical role of the ubiquitin/proteasome system in AR regulation, current research suggests that targeting AR degradation is a promising approach.
雄激素受体（AR）是一种属于核受体家族的转录因子，它介导雄激素在泌尿生殖结构发育中的作用。AR的表达在翻译后由泛素/蛋白酶体系统调节。这种调节涉及比典型降解更复杂的机制。泛素/蛋白酶体系统可能通过不参与受体周转的机制来调节AR。鉴于AR在性发育中的关键作用，这种复杂的调节尤为重要。AR信号失调可能是前列腺癌发生的一个因果因素。AR是前列腺癌治疗的主要靶点。由于泛素/蛋白酶体系统在AR调节中的关键作用，目前的研究表明，靶向AR降解是一种有前景的方法。
