Department of Oncology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, 315020, China.
Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo, 315211, China.
J Mol Med (Berl). 2022 Aug;100(8):1125-1144. doi: 10.1007/s00109-022-02229-9. Epub 2022 Jul 11.
Prostate cancer (PCa) is a malignant epithelial tumor of the prostate gland with a high male cancer incidence. Numerous studies indicate that abnormal function of ubiquitin-proteasome system (UPS) is associated with the progression and metastasis of PCa. E3 ubiquitin ligases, key components of UPS, determine the specificity of substrates, and substantial advances of E3 ubiquitin ligases have been reached recently. Herein, we introduce the structures and functions of E3 ubiquitin ligases and summarize the mechanisms of E3 ubiquitin ligases-related PCa signaling pathways. In addition, some progresses in the development of inhibitors targeting E3 ubiquitin ligases are also included.
前列腺癌（PCa）是一种发生于前列腺上皮的恶性肿瘤，男性癌症发病率较高。大量研究表明，泛素-蛋白酶体系统（UPS）的异常功能与 PCa 的进展和转移有关。E3 泛素连接酶是 UPS 的关键组成部分，决定了底物的特异性，最近在 E3 泛素连接酶方面取得了重大进展。本文介绍了 E3 泛素连接酶的结构和功能，并总结了 E3 泛素连接酶相关的 PCa 信号通路的机制。此外，还包括了针对 E3 泛素连接酶的抑制剂的一些研究进展。
