Jadhav K R, Shaikh I M, Ambade K W, Kadam V J
Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, CBD Belapur, Sector-8, Navi- Mumbai-400614, India.
Curr Drug Deliv. 2006 Jul;3(3):267-73. doi: 10.2174/156720106777731118.
The use of microemulsions as drug delivery vehicle has been an exciting and attractive area of research because of its many potential and extraordinary benefits. Microemulsions offer an interesting and potentially quite powerful alternative carrier system for drug delivery because of their high solubilization capacity, transparency, thermodynamic stability, ease of preparation, and high diffusion and absorption rates when compared to solvent without the surfactant system. The oral efficacy of microemulsion has already been proved by cyclosporine formulation (Neoral), but apart from oral route, microemulsions for other routes like dermal, transdermal, ocular, vaginal, rectal, buccal, periodontal, parenteral, and nasal delivery routes have also been developed. The present review focuses on various applications of microemulsions through different above mentioned routes and also gives idea about new application of micro emulsion as oral solid dosage form, as microreactors and as blood substitute.
由于微乳剂具有诸多潜在的非凡优势，将其用作药物递送载体一直是一个令人兴奋且颇具吸引力的研究领域。微乳剂因其高增溶能力、透明度、热力学稳定性、易于制备，以及与不含表面活性剂体系的溶剂相比具有高扩散和吸收速率，为药物递送提供了一种有趣且可能相当强大的替代载体系统。环孢素制剂（新山地明）已证明微乳剂的口服疗效，但除口服途径外，还开发了用于其他途径的微乳剂，如皮肤、透皮、眼部、阴道、直肠、口腔、牙周、肠胃外和鼻腔给药途径。本综述重点关注微乳剂通过上述不同途径的各种应用，还介绍了微乳剂作为口服固体剂型、微反应器和血液替代品的新应用。
