分子成像前景。
Molecular imaging perspectives.
作者信息
Cassidy Paul J, Radda George K
机构信息
Oxford Cardiac Metabolism Research Group, University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK.
出版信息
J R Soc Interface. 2005 Jun 22;2(3):133-44. doi: 10.1098/rsif.2005.0040.
Molecular imaging is an emerging technology at the life science/physical science interface which is set to revolutionize our understanding and treatment of disease. The tools of molecular imaging are the imaging modalities and their corresponding contrast agents. These facilitate interaction with a biological target at a molecular level in a number of ways. The diverse nature of molecular imaging requires knowledge from both the life and physical sciences for its successful development and implementation. The aim of this review is to introduce the subject of molecular imaging from both life science and physical science perspectives. However, we will restrict our coverage to the prominent in vivo molecular imaging modalities of magnetic resonance imaging, optical imaging and nuclear imaging. The physical basis of these imaging modalities, the use of contrast agents and the imaging parameters of sensitivity, temporal resolution and spatial resolution are described. Then, the specificity of contrast agents for targeting and sensing molecular events, and some applications of molecular imaging in biology and medicine are given. Finally, the diverse nature of molecular imaging and its reliance on interdisciplinary collaboration is discussed.
分子成像作为生命科学与物理科学交叉领域的一项新兴技术，必将彻底改变我们对疾病的理解和治疗方式。分子成像的工具包括成像模式及其相应的造影剂。这些工具通过多种方式促进在分子水平上与生物靶点的相互作用。分子成像的多样性决定了其成功开发和应用需要生命科学和物理科学两方面的知识。本综述旨在从生命科学和物理科学两个角度介绍分子成像这一主题。然而，我们将把讨论范围限制在磁共振成像、光学成像和核成像等突出的体内分子成像模式上。本文描述了这些成像模式的物理基础、造影剂的使用以及灵敏度、时间分辨率和空间分辨率等成像参数。接着，介绍了造影剂针对分子事件进行靶向和传感的特异性，以及分子成像在生物学和医学中的一些应用。最后，讨论了分子成像的多样性及其对跨学科合作的依赖。
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