University of Washington, Seattle, Washington, USA.
J Nucl Med. 2010 May 1;51 Suppl 1(Suppl 1):38S-50S. doi: 10.2967/jnumed.109.068155.
Cardiovascular molecular imaging is a new discipline that integrates scientific advances in both functional imaging and molecular probes to improve our understanding of the molecular basis of the cardiovascular system. These advances are driven by in vivo imaging of molecular processes in animals, usually small animals, and are rapidly moving toward clinical applications. Molecular imaging has the potential to revolutionize the diagnosis and treatment of cardiovascular disease. The 2 key components of all molecular imaging systems are the molecular contrast agents and the imaging system providing spatial and temporal localization of these agents within the body. They must deliver images with the appropriate sensitivity and specificity to drive clinical applications. As work in molecular contrast agents matures and highly sensitive and specific probes are developed, these systems will provide the imaging technologies required for translation into clinical tools. This is the promise of molecular medicine.
心血管分子影像学是一门新兴学科，它融合了功能成像和分子探针方面的科学进展，以增进我们对心血管系统分子基础的理解。这些进展源于对动物（通常是小动物）体内分子过程的活体成像，并迅速向临床应用推进。分子影像学有可能彻底改变心血管疾病的诊断和治疗方式。所有分子成像系统的 2 个关键组成部分是分子对比剂和提供这些对比剂在体内空间和时间定位的成像系统。它们必须提供具有适当灵敏度和特异性的图像，以推动临床应用。随着分子对比剂研究的成熟和高灵敏度、特异性探针的开发，这些系统将提供转化为临床工具所需的成像技术。这就是分子医学的前景。
