Lau Y T, Chern M S, Hung J S, Liang H C, Kao J F
Department of Physiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, R.O.C.
J Formos Med Assoc. 1991 Oct;90(10):1022-6.
The rate of erythrocyte Li-Na countertransport and cellular Na+ and K+ contents have been determined in normotensive (NT) and hypertensive (HT, essential hypertension) subjects in the presence and absence of atrial natriuretic peptide (ANP). The rate of Li-Na countertransport was significantly higher in erythrocytes of HT subjects, while the Na+ and K+ contents were not different between the NT and HT groups. We found that ANP (10(-9) and 10(-7) M) had no effect on either the rate of Li-Na countertransport or the cellular Na+ and K+ contents. Since ANP does not influence erythrocyte Na pump and Na-K-Cl cotransport, our results suggest that the Na transport systems of human erythrocytes do not respond to ANP and this lack of response in Li-Na countertransport is independent of the status of hypertension. These findings are consistent with the view that the rate of Li-Na countertransport of erythrocytes may serve as a useful genetic marker for essential hypertension in Chinese. However, the erythrocyte transport systems cannot provide further differentiation utilizing ANP response for essential hypertension.
在有和没有心房利钠肽（ANP）的情况下，测定了血压正常（NT）和高血压（HT，原发性高血压）受试者的红细胞锂-钠逆向转运速率以及细胞内钠和钾含量。HT受试者红细胞中的锂-钠逆向转运速率显著更高，而NT组和HT组之间的钠和钾含量并无差异。我们发现，ANP（10^(-9)和10^(-7) M）对锂-钠逆向转运速率以及细胞内钠和钾含量均无影响。由于ANP不影响红细胞钠泵和钠-钾-氯协同转运，我们的结果表明，人类红细胞的钠转运系统对ANP无反应，并且这种锂-钠逆向转运缺乏反应与高血压状态无关。这些发现与红细胞锂-钠逆向转运速率可能作为中国原发性高血压有用的遗传标志物这一观点一致。然而，红细胞转运系统无法利用ANP反应对原发性高血压进行进一步区分。
