Dambisya Y M, Chan K, Wong C L
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T.
Psychopharmacology (Berl). 1991;105(4):563-7. doi: 10.1007/BF02244381.
Ephedrine and phenylpropanolamine (PPA) (10 mg/kg) pretreatment intraperitoneally (IP) potentiated the antinociceptive effects of subcutaneous (SC) morphine (5 mg/kg) and codeine (60 mg/kg) in mice using the tail-flick method. Prior administration of propranolol (6 mg/kg, SC) 10 min before the sympathomimetics had no effect on this action. Phentolamine (2 mg/kg, SC), on the other hand, abolished the enhancing effects of ephedrine and PPA on opioid antinociception. Prazosin (2 mg/kg, SC) pretreatment did not significantly affect the potentiation of opioid antinociception by ephedrine and PPA, while yohimbine (4 mg/kg, SC) effectively antagonised this enhancing effect. None of the adrenoceptor antagonists had any effect on the tail-flick reaction time on their own in the doses used, and neither did they affect opioid antinociceptive responses. It is concluded that ephedrine and PPA potentiate the antinociceptive effects of morphine and codeine, most probably through an action on alpha 2-adrenoceptors.
使用甩尾法，麻黄碱和苯丙醇胺（PPA）（10毫克/千克）腹腔注射预处理增强了皮下注射（SC）吗啡（5毫克/千克）和可待因（60毫克/千克）对小鼠的镇痛作用。在给予拟交感神经药前10分钟预先皮下注射普萘洛尔（6毫克/千克）对此作用无影响。另一方面，酚妥拉明（2毫克/千克，皮下注射）消除了麻黄碱和PPA对阿片类药物镇痛作用的增强效果。哌唑嗪（2毫克/千克，皮下注射）预处理对麻黄碱和PPA增强阿片类药物镇痛作用无显著影响，而育亨宾（4毫克/千克，皮下注射）有效拮抗了这种增强作用。在所使用的剂量下，没有一种肾上腺素能受体拮抗剂单独对甩尾反应时间有任何影响，它们也不影响阿片类药物的镇痛反应。得出的结论是，麻黄碱和PPA增强吗啡和可待因的镇痛作用，很可能是通过作用于α2肾上腺素能受体实现的。
