Dambisya Y M, Wong C L, Chan K
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T.
Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:5-12.
The effects of ephedrine and phenylpropanolamine on the antinociceptive activities of morphine and codeine were investigated. Both morphine and codeine exhibited dose-dependent antinociceptive activities in the tail flick test. Ephedrine (5, 10 and 20 mg/kg) and phenylpropanolamine (5, 10 and 20 mg/kg) showed no antinociceptive effect when administered alone. The antinociceptive effects of morphine were enhanced in mice pretreated with ephedrine or phenylpropanolamine. similarly, codeine antinociception was increased in mice pretreated with ephedrine or phenylpropanolamine. In all cases, the ED50 values and single dose comparisons were shifted in the same direction. These effects on the antinociceptive potencies of morphine and codeine were found to be dose-dependent, being statistically significant at the higher dose levels of ephedrine and phenylpropanolamine used in the present study.
研究了麻黄碱和去氧肾上腺素对吗啡和可待因镇痛活性的影响。在甩尾试验中，吗啡和可待因均表现出剂量依赖性的镇痛活性。单独给予麻黄碱（5、10和20毫克/千克）和去氧肾上腺素（5、10和20毫克/千克）时未显示出镇痛作用。用麻黄碱或去氧肾上腺素预处理的小鼠中，吗啡的镇痛作用增强。同样，用麻黄碱或去氧肾上腺素预处理的小鼠中，可待因的镇痛作用增强。在所有情况下，半数有效量（ED50）值和单剂量比较均向相同方向变化。发现这些对吗啡和可待因镇痛效力的影响具有剂量依赖性，在本研究中使用的麻黄碱和去氧肾上腺素较高剂量水平时具有统计学意义。
