Dambisya Y M, Wong C L, Chan K
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong.
Methods Find Exp Clin Pharmacol. 1991 May;13(4):239-48.
The effects of chronic pretreatment with ephedrine and phenylpropanolamine (PPA) on the antinociceptive activities of morphine and codeine, as well as their effects on the induction and expression of tolerance to, and dependence on morphine and codeine in mice are reported. Chronic pretreatment with ephedrine or PPA attenuated the antinociceptive effects of subsequently administered morphine or codeine. When administered during the induction phase, sympathomimetics enhanced opiate tolerance with little or no effect on the development of physical dependence. Given in the expression phase, ephedrine and PPA did not significantly affect tolerance, whereas there was significant suppression of withdrawal signs. The possible implications of these results are discussed.
报告了麻黄碱和苯丙醇胺（PPA）长期预处理对吗啡和可待因镇痛活性的影响，以及它们对小鼠吗啡和可待因耐受性诱导、表达及依赖性的影响。麻黄碱或PPA长期预处理减弱了随后给予的吗啡或可待因的镇痛作用。在诱导期给予拟交感神经药可增强阿片类药物耐受性，对身体依赖性的发展影响很小或没有影响。在表达期给予麻黄碱和PPA对耐受性没有显著影响，而对戒断症状有显著抑制作用。讨论了这些结果可能的意义。
