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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Caseby R H, Fairweather I, Harriott M

School of Biology and Biochemistry, Queen's University of Belfast, U.K.

Comp Biochem Physiol A Comp Physiol. 1991;100(4):867-71. doi: 10.1016/0300-9629(91)90305-v.

The ionic response of the liver fluke, Fasciola hepatica to perturbation of Na,K-pump activity has been determined by atomic absorption spectrophotometry. 2. The Na+/K(+)-ATPase inhibitor ouabain (1 x 10(-4) M) induced a marked reduction in K+ levels; Na+ and Ca2+ levels also fell. 3. The sodium ionophore monensin (1 x 10(-4) M) also caused a decrease in K+ levels, to below that of Na+. 4. Brief pretreatment with ouabain (1 x 10(-4) M, 15 min) followed by monensin treatment did not affect the decline in K+ levels, but did prevent the short-lived Na+ decline observed with monensin alone. 5. The deacetylated (amine) metabolite of the fasciolicide diamphenethide caused a short-lived drop in Na+ levels, but otherwise produced little change in ion levels within the fluke.

Caseby R H, Fairweather I, Harriott M

School of Biology and Biochemistry, Queen's University of Belfast, U.K.

Comp Biochem Physiol A Comp Physiol. 1991;100(4):867-71. doi: 10.1016/0300-9629(91)90305-v.

The ionic response of the liver fluke, Fasciola hepatica to perturbation of Na,K-pump activity has been determined by atomic absorption spectrophotometry. 2. The Na+/K(+)-ATPase inhibitor ouabain (1 x 10(-4) M) induced a marked reduction in K+ levels; Na+ and Ca2+ levels also fell. 3. The sodium ionophore monensin (1 x 10(-4) M) also caused a decrease in K+ levels, to below that of Na+. 4. Brief pretreatment with ouabain (1 x 10(-4) M, 15 min) followed by monensin treatment did not affect the decline in K+ levels, but did prevent the short-lived Na+ decline observed with monensin alone. 5. The deacetylated (amine) metabolite of the fasciolicide diamphenethide caused a short-lived drop in Na+ levels, but otherwise produced little change in ion levels within the fluke.