小鼠嗅觉感觉神经元中的质膜钙泵
Plasma membrane calcium pumps in mouse olfactory sensory neurons.
作者信息
Weeraratne S Dilhan, Valentine Megan, Cusick Matthew, Delay Rona, Van Houten Judith L
机构信息
Department of Biology, University of Vermont, 109 Carrigan Drive, Burlington, VT 05405, USA.
出版信息
Chem Senses. 2006 Oct;31(8):725-30. doi: 10.1093/chemse/bjl014. Epub 2006 Jul 19.
Abstract
We report here the presence of specific plasma membrane calcium pumps (PMCAs) in mouse olfactory sensory neurons. All 4 isoforms are present as shown by deconvolution microscopy, and the specific splice variants are identified by reverse transcriptase (RT)-polymerase chain reaction (PCR). The PMCAs are present on the cell body, dendrite, knob, and cilia, but the different isoforms of PMCAs are not identical in their distributions. The PMCAs are positioned to play a role in calcium clearance after stimulation.
摘要
我们在此报告小鼠嗅觉感觉神经元中存在特定的质膜钙泵（PMCA）。通过去卷积显微镜显示所有4种亚型均存在，并且通过逆转录酶（RT）-聚合酶链反应（PCR）鉴定了特定的剪接变体。PMCA存在于细胞体、树突、嗅小球和纤毛上，但PMCA的不同亚型在其分布上并不相同。PMCA的定位使其在刺激后清除钙的过程中发挥作用。
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