小鼠嗅觉感觉神经元中的质膜钙泵
Plasma membrane calcium pumps in mouse olfactory sensory neurons.
作者信息
Weeraratne S Dilhan, Valentine Megan, Cusick Matthew, Delay Rona, Van Houten Judith L
机构信息
Department of Biology, University of Vermont, 109 Carrigan Drive, Burlington, VT 05405, USA.
出版信息
Chem Senses. 2006 Oct;31(8):725-30. doi: 10.1093/chemse/bjl014. Epub 2006 Jul 19.
Abstract
We report here the presence of specific plasma membrane calcium pumps (PMCAs) in mouse olfactory sensory neurons. All 4 isoforms are present as shown by deconvolution microscopy, and the specific splice variants are identified by reverse transcriptase (RT)-polymerase chain reaction (PCR). The PMCAs are present on the cell body, dendrite, knob, and cilia, but the different isoforms of PMCAs are not identical in their distributions. The PMCAs are positioned to play a role in calcium clearance after stimulation.
摘要
我们在此报告小鼠嗅觉感觉神经元中存在特定的质膜钙泵（PMCA）。通过去卷积显微镜显示所有4种亚型均存在，并且通过逆转录酶（RT）-聚合酶链反应（PCR）鉴定了特定的剪接变体。PMCA存在于细胞体、树突、嗅小球和纤毛上，但PMCA的不同亚型在其分布上并不相同。PMCA的定位使其在刺激后清除钙的过程中发挥作用。
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J Mol Cell Cardiol. 2005 Sep;39(3):403-6. doi: 10.1016/j.yjmcc.2005.04.007.
2
A comparative functional analysis of plasma membrane Ca2+ pump isoforms in intact cells.完整细胞中质膜钙泵同工型的比较功能分析
J Biol Chem. 2003 Jul 4;278(27):24500-8. doi: 10.1074/jbc.M300784200. Epub 2003 Apr 25.
3
Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels.钙/钙调蛋白对嗅觉和视杆细胞环核苷酸门控离子通道的调节作用
J Biol Chem. 2003 May 23;278(21):18705-8. doi: 10.1074/jbc.R300001200. Epub 2003 Mar 7.
4
Transient rise in intracellular calcium produces a long-lasting increase in plasma membrane calcium pump activity in rat sensory neurons.细胞内钙的短暂升高会使大鼠感觉神经元的质膜钙泵活性产生持久增加。
J Neurochem. 2002 Nov;83(4):1002-8. doi: 10.1046/j.1471-4159.2002.01221.x.
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6
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7
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J Neurophysiol. 1999 Jun;81(6):2675-82. doi: 10.1152/jn.1999.81.6.2675.
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